CAS: 6890-88-6; (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-Pentamethyl-17-((R)-6-Methyl-5-Methyleneheptan-2-yl)-2,3,4,5,6,7,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-3-Ol

上下游产品

3β-acetoxy-24-methylene-lanost-8-ene lanosterol tirucallol S-Adenosyl-L-methionineformaldehyd formic acid 3-O-Acetyl-euphorbol O-Benzoyl-euphorbolO-Benzoyl-euphorbol

📜羊毛甾醇置于paracoccidiodes Brasiliensis Sterol C24-Methyltransferase,Recombinant,Adomet体系中,用55%的收率获得产物齿孔醇
参考文献:芸苔甾醇生物合成中涉及的真菌固醇c24-甲基转移酶的克隆,机理和功能分析.
标题:芸苔甾醇生物合成中涉及的真菌固醇c24-甲基转移酶的克隆,机理和功能分析.
摘要:已证明,在非包膜真菌巴西副球菌(paracoccidiodes Brasiliensis)(pb)中形成24-烷基甾醇的第一步涉及到羊毛脂的c24甲基化为eburicol(24(28)-亚甲基-24,25-二氢羊毛甾醇).代谢产物共存的基础.采用基于相似性的克隆策略来获得与c24-甲基化反应有关的固醇c24-甲基转移酶(smt)对应的cdna克隆.制备为重组融合蛋白(his / Trx / S)的所得催化剂在大肠杆菌bl21(c43)中表达,显示对羊毛甾醇具有底物特异性,并反应生成单一的环外亚甲基产物.全长cdna具有1131个碱基对的开放阅读框,编码377个残基的蛋白质,计算的分子量为42,502Da.酶促c24甲基化的k(mapp)为38Microm,K(catapp)为0.14Min(-1).出乎意料的是,"植物"环戊烯醇以高收率被催化反应生成24(28)-亚甲基环烷醇,这与构象论点相符,有
DOI:10.1016/j.Bbalip.2010.06.007

专利信息

专利号:US-8647875-B2
优先权日:2004-10-15
标题 :Enzymes involved in triterpene synthesis
发明人：OSBOURN ANNE; QI XIAOQUAN
权利人:OSBOURN ANNE; QI XIAOQUAN; PLANT BIOSCIENCES LTD
摘要:This invention relates to isolated polynucleotides encoding a CYP51H. The invention also relates to the construction of recombinant DNA constructs comprising all or a portion of the isolated polynucleotide of the invention, in sense or antisense orientation, operably linked to at least one regulatory sequence.

专利号:WO-2022018767-A1
优先权日:2020-07-24
标题 :Agrochemical composition comprising sdhi fungicides.
发明人：PATEL Dipakkumar; SHAH KENAL V; SHAH BHAVESH V; DABHODIA KAWARLAL
权利人:RAJDHANI PETROCHEMICALS PRIVATE LTD
摘要:Agrochemical composition comprising SDHI fungicides. The present invention further relates to a synergistic fungicidal compositions comprising bioactive amounts of a fungicide selected from SDHI (Succinate dehydrogenase inhibitors) group or mixture thereof; at least one more fungicide selected from the class of QoI (Quinone outside Inhibitors), QiI-fungicides (Quinone inside Inhibitors), Lipid or transport and membrane synthesis inhibitors, Sterol biosynthesis Inhibitors, Melanin synthesis in cell wall Inhibitors, compound with unknow mode of action, multisite contact fungicides, Ipflufenoquin, Pyridachlometyl or mixture thereof; at least one more compound selected from plant health additive or mixture thereof. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic agrochemical fungicidal compositions, wherein active ingredient present in fixed ratio shows synergy in fungicidal activity.