CAS: 68194-10-5; 2,3,3',5',6-Pentachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,这些合成有机化学品以其环境持久性和潜在毒性而著称,该化合物有5个氯原子,以联苯结构替代,特别是2,3,3',5'和6个位置,其物理特性包括水中的高熔点和低溶解性,使其在有机溶剂和油中更易溶解.2,3,3',5',6-五溴二苯醚具有疏水性,这助长了其在活生物体中的生物累积性以及远距离环境迁移的潜力.由于其稳定性和耐降解性,它造成了重大的生态和健康风险,包括内分泌干扰和致癌效应.许多国家都实施了管制措施,以限制多氯联苯的使用和释放,包括这种化合物在内,因为它们对环境的有害影响和在生态系统中的持久性.

英文名称2,3,3',5',6-Pentachlorobiphenyl
中文名称2,3,3',5',6-五氯联苯
IUPAC名称1,2,4-trichloro-3-(3,5-dichlorophenyl)benzene
其它别名2,3,3',5',6-Pentachlorobiphenyl; 2,3,6,3',5'-Pentachlorobiphenyl
CAS编号68194-10-5
MFCD编号:MFCD00792645
FDA UNII编号:6P780301P3
分子式:C12H5Cl5分子量:326.43
产品CID: 1670742
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: YDGFMDPEJCJZEV-UHFFFAOYSA-N
1S/C12H5Cl5/c13-7-3-6(4-8(14)5-7)11-9(15)1-2-10(16)12(11)17/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

3,5-dichloroiodobenzene 1,2,4-trichloro-3-iodobenzene

合成工艺路线路线简述

📜3,5-二氯碘苯,1,2,4-三氯-3-碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,3,3',5',6-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4