📜Methyl-(Tri-O-Benzoyl-6-Deoxy-α-D-Altropyranoside)置于甲醇,Sodium Methylate体系中,化学反应生成 6-脱氧阿卓糖 参考文献:L-Fuco-4-Ketose,A New Sugar Produced By The Action Of Acetobacter Suboxydans On L-Fucitol1 标题:L-Fuco-4-Ketose,A New Sugar Produced By The Action Of Acetobacter Suboxydans On L-Fucitol1 摘要: DOI:10.1021/ja01167A025
专利号:US-12188072-B2 优先权日:2018-03-19 标题 :Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates 发明人:JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN 权利人:UNIV NORTHWESTERN; UNIV CORNELL 摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
专利号:US-2022395800-A1 优先权日:2019-11-04 标题:Device for automated synthesis of oligo- and polysaccharides 发明人:SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO 权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A 摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.
专利号:US-7435816-B2 优先权日:2003-04-30 标 题 :Synthesis of solanum glycosides 发明人:SHAHID MOHAMMED 权利人:SHAHID MOHAMMED 摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R 1 is a benzylidene, 4-nitrobenzylidene or 4-methoxybenzylidine group, and each R 2 independently is a benzoyl, acetyl or pivaloyl group:
专利号:EP-1421100-B1 优先权日:2001-08-21 标 题 :Chemical synthesis of solamargine 发明人:SHAHID MOHAMMED 权利人:GLYCOMED SCIENCES LTD 摘要:The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solamargine as well as to novel beta-monosaccharide Intermediate compounds.
专利号:WO-2018002957-A8 优先权日:2016-06-29 标 题 :A method for synthesis of 6-deoxy-l-hexoses from l-rhamnose 发明人:KULKARNI SUVARN SUBHASH; SANAPALA SOMESWARA RAO 权利人:INDIAN INST TECHNOLOGY BOMBAY 摘要:The present invention relates to a process for synthesis of 6-Deoxy-L-Hexoses from L-Rhamnose comprising the steps of optional regioselective protection of C2-, C3- and/or C4-OH of the L- Rhamnose of formula (1) to obtain compounds of formulae (2) and subjecting said compounds of formulae 2 to triflation followed by nitrite anion or water mediated inversion to obtain 6-deoxy- L-Hexoses of formulae (3).
专利号:US-5945529-A 优先权日:1996-07-19 标题:Synthesis of polyol fatty acid polyesters using column with inert gas stripping 发明人:CORRIGAN PATRICK JOSEPH; KENNEALLY COREY JAMES; GRANBERG ERIC PAUL 权利人:PROCTER & GAMBLE 摘要:Processes for the synthesis of polyol fatty acid polyester by transesterification of a polyol comprise reacting polyol with a first portion of fatty acid lower alkyl ester to provide a first step reaction product in which substantially all of the polyol is reacted with at least one fatty acid lower alkyl ester. The processes then employ a multistage column providing substantial plug flow of liquid therein for further transesterification of the first step reaction product. Partially esterified polyol, a second portion of fatty acid lower alkyl ester and catalyst are fed to the column to form a mixture and cause further transesterification of the partially esterified polyol and fatty acid lower alkyl ester, with lower alkyl alcohol being formed as a by product. The resulting liquid mixture of reactants and product is passed in a first direction between adjacent stages through the column for further reaction of partially esterified polyol with fatty acid lower alkyl ester. An inert stripping or sparging gas is fed through the column in a second direction between adjacent stages, counter current to the flow of the liquid mixture between adjacent stages in the first direction, with radial shear agitation. The lower alkyl alcohol by-product of the polyol-fatty acid lower alkyl ester reaction is transferred from the liquid mixture to the inert gas.
参考文献:10.1007/s10482-011-9588-8 摘要:Miao Q, Qin S, Bian GK, Yuan B, Xing K, Zhang YJ, Li Q, Tang SK, Li WJ, Jiang JH. Amycolatopsis endophytica sp. nov., a novel endophytic actinomycete isolated from oil-seed plant Jatropha curcas L. Antonie Van Leeuwenhoek. 2011 Oct;100(3):333–9. doi: 10.1007/s10482-011-9588-8. 参考文献:10.1186/s12866-017-0943-4 摘要:Hong TP, Carter MQ, Struffi P, Casonato S, Hao Y, Lam JS, Lory S, Jousson O. Conjugative type IVb pilus recognizes lipopolysaccharide of recipient cells to initiate PAPI-1 pathogenicity island transfer in Pseudomonas aeruginosa. BMC Microbiology. 2017 Feb 07;17(1):31. doi: 10.1186/s12866-017-0943-4. 参考文献:10.1007/bf01240135 摘要:Zhu H, Zollner TM, Klein-Franke A, Anderer FA. Enhancement of MHC-unrestricted cytotoxic activity of human CD56+ CD3− natural killer (NK) cells and CD3+ T cells by rhamnogalacturonan: Target cell specificity and activity against NK-insensitive targets. Journal of Cancer Research and Clinical Oncology. 1994 Jul;120(7):383–8. doi: 10.1007/bf01240135. 参考文献:10.1007/bf02538423 摘要:KREGER-VAN RIJ NJ. Taxonomy of Cryptococcus neoformans and its variety uniguttulatus. Antonie Van Leeuwenhoek. 1961;27():59–64. doi: 10.1007/bf02538423. 参考文献:10.1023/b:glyc.0000038290.74944.65 摘要:Novotny R, Pfoestl A, Messner P, Schäffer C. Genetic organization of chromosomal S-layer glycan biosynthesis loci of Bacillaceae. Glycoconj J. 2004;20(7-8):435–47. doi: 10.1023/b:glyc.0000038290.74944.65.