CAS: 62932-94-9; 2-Bromo-1-[4-Hydroxy-3-(Hydroxymethyl) Phenyl]Ethan-1-One

上下游产品

5-溴乙酰基-2-羟基苯甲醛 5-(2-Bromoacetyl)-2-Hydroxybenzaldehyde 115787-50-3
4-乙酰氧基-3-乙酰氧基甲基-Alpha-溴苯乙酮 3'-Acetoxymethyl-4'-Acetoxy-2-Bromoacetophenone 24085-07-2
4-羟基-3-羟甲基苯乙酮二乙酸酯 4'-Acetoxy-3'-(Acetoxymethyl)Acetophenone 24085-06-1

4-羟基-3-羟甲基苯乙酮二乙酸酯置于polyvinylpyridinium Bromide Perbromide Resin,氢溴酸体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应生成 2-溴-1-[4-羟基-3-(羟基甲基)苯基]-1-乙酮
参考文献:Synthesis Of The β2 Agonist (R)-Salmeterol Using A Sequence Of Supported Reagents And Scavenging Agents
标题:Synthesis Of The β2 Agonist (R)-Salmeterol Using A Sequence Of Supported Reagents And Scavenging Agents
摘要:Graphicthe Enantioselective Synthesis Of (R)-Salmeterol Has Been Achieved By Using A Sequence Of Supported Reagents And Sequestering Agents. The Saligenin Core Was Installed By A Regiospecific Alkylation And A Chiral Auxiliary Approach Was Employed To Introduce The Desired Stereochemistry Via A Diastereoselective Reduction.
DOI:10.1021/ol020128G

专利信息

专利号:WO-2023097678-A1
优先权日:2021-12-03
标 题:Method for synthesizing (r)-5-(2,2-dimethyl-4h-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one
发明人：ZHOU ZHANGTAO; YE WEIPING; PHILLIS ANDREW TOROA; XU LI; HUANG ZHINING; FU LI
权利人:GUANGDONG RAFFLES PHARMATECH CO LTD
摘要:A method for synthesizing (R)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one. The synthesis route of the method is: where X is Br, Cl or I, preferably Br. Preferably, chiral phenyloxazolidin-2-one is prepared from a 2-bromoacetophenone compound in a high-selectivity manner by means of protection, nucleophilic attack, asymmetric transfer hydrogenation, and finally CDI ring closing.

专利号:CN-115286521-B
优先权日:2022-07-11
标 题 :A kind of synthesis method of levalbuterol hydrochloride