CAS: 5621-02-3; 2-Dimethylaminopyrimidine

英文名称2-Dimethylaminopyrimidine
中文名称2-二甲氨基嘧啶
IUPAC名称2-Dimethylaminopyrimidine
其它别名2-Pyrimidinamine, N,N-Dimethyl- (9Ci); N,N-Dimethyl-2-Pyrimidinamine; N,N-Dimethylpyrimidin-2-Amine
CAS编号5621-02-3
MFCD编号:MFCD11846467
分子式:C6H9N3分子量:123.16
产品CID: 2305164
产品分类医药中间体 → 嘧啶类化合物

相似结构搜索
产品信息参考;
InChIKey: OUMGIYIBWRLOAF-UHFFFAOYSA-N
InChI=1S/C6H9N3/c1-9(2)6-7-4-3-5-8-6/h3-5H,1-2H3
计算化学: 氢键受体数3.0氢键供体数*可旋转键数1.0

MSDS等安全信息

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合成工艺路线路线简述

合成目标产物 2-Pyrimidinamine, N,N-Dimethyl- (9CI) 主要起始原料 2-Chloropyrimidine And N,N-Dimethyloctylamine
(文献来源)合成步骤主要原料 2-Chloropyrimidine 和 N,N-Dimethyloctylamine

📜2-Dimethylamino-Pyrimidine-5-Carboxylic Acid Ethyl Ester置于氢氧化钾体系中,用甲醇作为反应溶剂,化学反应 6.5H,反应生成 2-二甲氨基嘧啶
参考文献:新型嘧啶衍生物的合成及其强心活性:晶体学和量子化学研究.
标题:新型嘧啶衍生物的合成及其强心活性:晶体学和量子化学研究.
摘要:乙基或甲基4-取代或未取代的2-(二甲基氨基)-5-嘧啶羧酸酯10-20的合成,主要是通过将乙基或甲基[2-[(二甲基氨基)亚甲基]-3-氧代链烷酸酯与1,描述了1-二甲基胍.将上述酯水解成相对的羧酸21-30,将其脱羧成相应的2,4-二取代的嘧啶31-40.在利血平治疗的豚鼠自发搏动和电动心房中评估了所有新合成的嘧啶.在两种心房制剂中,将它们的作用与米力农诱导的作用进行了比较.化合物28(4-苄基-2-(二甲基氨基)-5-嘧啶羧酸)是最有效的正性肌力药,而相应的甲酯17降低了豚鼠心房的收缩力和频率.对内源性腺苷对心脏产生的负面影响的拮抗作用似乎与化合物28的收缩活性有关.相反,化合物17在嘌呤能抑制(a1)受体上可能是部分激动剂.在17和28日进行了x射线分析,分子模型研究也扩展到了相关的衍生物,使得该系列化合物的结构和正性离子活性之间可能合理化.
DOI:10.1021/jm9508649

海关参考信息

2921199090-其他无环单胺
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专利信息

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:WO-9847910-A1
优先权日:1997-04-21
标题:Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
权利人:NEXSTAR PHARMACEUTICALS INC; PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING; HILL KEN; SMITH RANDALL S
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-5874532-A
优先权日:1997-01-08
标题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6001966-A
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:RU-2069214-C1
优先权日:1994-03-29
标题 :$$$-phosphate,n,p-nonprotected phosphothioate oligodeoxynucleotides as parental compounds for synthesis of phosphothioate oligonucleotide reagents for biotechnological processes, phosphothioate oligonucleotide derivatives containing 3'- and/or 5'-bound chemical groups as phosphothioate oligonucleotide reagents for biotechnological processes and method of their synthesis

专利号:US-10995078-B2
优先权日:2013-03-13
标题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

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合成参考文献

摘要:D.J. Brown, B.T. England and J.M. Lyall. J. Chem. Soc., C 1966, 226.
摘要:F. Cruège, G. Girault, S. Coustal, J. Lascombe and P. Rumpf. Bull. Soc. Chim. France 1970, 3889.
参考文献:10.1007/s00894-002-0075-z
摘要:Hennemann M, Clark T. A QSPR-Approach to the Estimation of the p K HB of Six-Membered Nitrogen-Heterocycles using Quantum Mechanically Derived Descriptors. Journal of Molecular Modeling. 2002 Apr 01;8(4):95–101. doi: 10.1007/s00894-002-0075-z.
参考文献:10.1007/s00216-008-2179-5
摘要:Zhao D, He L, Pu C, Deng A. A highly sensitive and specific polyclonal antibody-based enzyme-linked immunosorbent assay for detection of antibiotic olaquindox in animal feed samples. Analytical and Bioanalytical Chemistry. 2008 May 29;391(7):2653–61. doi: 10.1007/s00216-008-2179-5.