CAS: 55736-04-4; 1-(2-Chloro-6-Hydroxyphenyl)Ethanone

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CAS号89999-90-6 2-氯-6-羟基苯腈 | CAS号75-16-1 甲基溴化镁 | CAS号881883-32-5 1-(2-氯-6-甲氧基苯基)乙酮 | CAS号108-43-0 3-氯酚 | CAS号91105-99-6 1-chloro-3-(met... | CAS号6575-10-6 2-氯-6-甲氧基氰苯

2-氯-6-甲氧基氰苯置于三溴化硼体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 27.0H,反应生成 1-(2-氯-6-羟基苯基)乙酮
参考文献:Chromenones As Potent Bradykinin B1 Antagonists
标题:Chromenones As Potent Bradykinin B1 Antagonists
摘要:A Series Of Fused 6,6-Bicyclic Chromenones Was Investigated For Activity Against The Bradykinin B1 Receptor. Sar Studies Based On A Pharmacophore Model Revealed Compounds With High Affinity For Both Human And Rabbit B1. These Compounds Demonstrated Favorable Pharmacokinetic Properties And 5-Chlorochromenone 15 Was Efficacious In A Carrageenan-Induced Mechanical Hyperalgesia Model For Chronic Pain. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2011.10.068

专利信息

专利号:WO-2011047481-A1
优先权日:2009-10-23
标题 :Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
权利人:MERCK FROSST CANADA LTD; FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-8383643-B2
优先权日:2009-07-28
标题 :Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
权利人:MERCK CANADA INC; LECLERC JEAN-PHILIPPE; LI CHUN-SING; MORADEI OSCAR MIGUEL
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.