CAS: 455-37-8; 3-Fluorobenzamide

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CAS号201230-82-2 carbon monoxide | CAS号1121-86-4 3-氟碘苯 | CAS号1711-07-5 3-氟苯甲酰氯 | CAS号331-25-9 3-氟苯乙酸 | CAS号32222-47-2 2-(3-fluorophen... | CAS号456-48-4 3-氟苯甲醛 | CAS号403-54-3 3-氟苯甲腈 | CAS号456-47-3 3-氟苄醇 | CAS号88229-23-6 3-fluoro-N-prop... | CAS号455-38-9 间氟苯甲酸 | CAS号455-38-9 间氟苯甲酸 | CAS号455-68-5 3-氟苯甲酸甲酯 | CAS号3556-52-3 3-Fluoro-4-nitr... | CAS号324-57-2 2-(3-fluorophen... | CAS号1629-09-0 N-苯基-3-氟苯甲酰胺 | CAS号72505-20-5 3-氟硫代苯甲酰胺 | CAS号58955-03-6 3-fluoro-N-(4-m... | CAS号52059-64-0 5-(3-fluorophen...

📜3-氟苯腈置于水体系中,化学反应 0.75H,以86%的收率获得产物间氟苯甲酰胺
参考文献:在无碱条件下,支持的金纳米颗粒催化的微波辅助水合将腈转化为酰胺
标题:在无碱条件下,支持的金纳米颗粒催化的微波辅助水合将腈转化为酰胺
摘要:聚苯乙烯负载的金(au @ Ps)纳米粒子是通过还原沉积法合成的,并具有紫外可见,Xrd,Tem,Saed,Edx和xps研究的特征.在微波辐射下,Au @ Ps用作催化剂将腈在水中水合成酰胺.发现几种官能化的芳族,杂环和脂族腈可用于合成相应的酰胺,而无需通过碱,配体和载体活化水.在水介导的反应条件下,该催化剂的易于回收,可忽略不计的沥滤和多达八次运行的可回收性是其优点.
DOI:10.1002/adsc.201600199

专利信息

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:US-8513241-B2
优先权日:2008-03-28
标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:CN-109369555-A
优先权日:2018-11-29
标题 :A kind of method of microwave radiation benzamide compound synthesis benzoxazoles in water phase