CAS: 4465-65-0; (4R,4As,12Ar)-4-(Dimethylamino)-1,10,11,12A-Tetrahydroxy-6-Methyl-3,12-Dioxo-4A,5-Dihydro-4H-Tetracene-2-Carboxamide,Hydrochloride

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CAS号13803-65-1 盐酸脱水四环素 | CAS号13803-65-1 盐酸脱水四环素

专利信息

专利号:US-2005106689-A1
优先权日:2002-03-21
标 题:Synthesis of aminocrotonates
发明人：BRAUN MAX; BRAUKMUELLER SASKIA
权利人:SOLVAY FLUOR & DERIVATE
摘要:3-aminocrotonate compounds, e.g. diesters, which are substituted on the C-4 atom by at least two chlorine and/or fluorine atoms, are produced by reacting corresponding acetoacetate compounds with ammonia and primary and secondary amines while simultaneously or subsequently eliminating water. The reaction is carried out in the presence of onium salts formed from primary or secondary amines and carboxylic acids. Preferably, two phases are formed; one phase containing the crotonate compound product with a good degree of purity and the other phase containing the onium salt and water.

专利号:US-5194666-A
优先权日:1992-07-30
标 题 :Process for preparing esters of 3,5,6-trichlorosalicyclic acid
发明人：SEDLAK JOHN A; HIGGINS MARK A; ESSENFELD AMY P
权利人:AMERICAN CYANAMID CO
摘要:An improved process for the synthesis of esters of 3,5,6-trichlorosalicylic acid in quantitative yield comprises reacting the acid with an alcohol under distillation conditions in the presence of a titanium ester or chelate catalyst, whereby byproduct ether formation from the alcohol is suppressed. The process is especially applicable to a process by which salicylic acid is chlorinated first in concentrated sulfuric acid and then with iodine catalyst to make the trichlorosalicylic acid which is extracted and then reacted with an alcohol and a titanium catalyst to make the ester.