CAS: 42523-29-5; 2,7-Dihydroxy-9-Fluorenone

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CAS号53197-57-2 4, 4'-二羟基-[1, 1... | CAS号53133-99-6 (7-acetyloxy-9-... | CAS号71597-85-8 4-羟基苯硼酸 | CAS号154607-00-8 2-溴-5-羟基苯甲酸甲酯 | CAS号86-73-7 芴 | CAS号42523-28-4 2,7-dimethoxy-9... | CAS号84185-72-8 4-hydroxy-7-(4-... | CAS号84185-84-2 4-hydroxy-4'-me... | CAS号696-62-8 4-碘苯甲醚 | CAS号299167-98-9 2,7-bis[2-(2-hy... | CAS号303735-64-0 2,7-diethoxyflu... | CAS号27591-97-5 替洛隆 | CAS号123305-05-5 methyl 2-[7-(2-... | CAS号69742-04-7 2,7-dipentoxyfl... | CAS号5043-54-9 9H-芴-2,7-二醇 | CAS号619335-38-5 2,7-bis[2-[2-(2...

[1,1-联苯]-2-羧酸,4,4-二羟基置于硫酸,Zinc(II) Chloride体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 2,7-二羟基-9-芴酮
参考文献:一种具有明显的ifn-α诱导活性的盐酸双氯隆的有效合成方法.
标题:一种具有明显的ifn-α诱导活性的盐酸双氯隆的有效合成方法.
摘要:盐酸噻氯隆(1)具有诱导干扰素抵抗病原体感染的巨大潜力.在本文中,我们描述了一种方便的制备2,7-二羟基芴-9-一(2)的方法,这是制备替洛龙二盐酸盐(1)的常用药物中间体.在该新方法中,在较温和的条件下以较高的收率进行了4,4'-二羟基-[1,1'-联苯]-2-羧酸的甲基酯化反应(4),这在化合物的制备中起着重要作用2.通过熔点,Ir,Ms和1 H-NMR表征相关中间体和目标化合物的结构.此外,合成的盐酸氢吡咯酮在12 H内对小鼠干扰素-α(ifn-α)的诱导具有明显的作用,直至24 H观测到峰值.
DOI:10.3390/molecules201219781

专利信息

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人：JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:US-11420997-B2
优先权日:2018-04-13
标题:Peptide synthesis method
发明人：SUZUKI HIDEAKI; MUTO SUSUMU; FUJITA SHUJI; KUBO DAISUKE
权利人:JITSUBO CO LTD
摘要:The present invention has an object of shortening the process time and reducing use of a poor solvent for solidifying a carrier (Tag)-peptide component, by removing impurities without conducting solid-liquid separation (condensation, solid-liquid separation and drying operation) of a Tag-peptide component, in an Fmoc method using a Tag for liquid phase peptide synthesis. Provided is the peptide synthesis method that includes the following steps a-d: step a: a carrier-protected amino acid, carrier-protected peptide, or a carrier-protected amino acid amide, and an N-Fmoc-protected amino acid or an N-Fmoc-protected peptide are condensed in an organic solvent or a mixed solution of organic solvents, to obtain an N-Fmoc-carrier-protected peptide, step b: a water-soluble amine is added to the reaction solution after the condensation reaction, step c: the Fmoc group is deprotected from the protected amino group in the presence of a water-soluble amine, and step d: the reaction solution is neutralized by adding an acid, and further, by adding and washing with an acidic aqueous solution, then, by liquid-liquid separation an aqueous layer is removed to obtain an organic layer.

专利号:WO-2023067624-A1
优先权日:2021-10-20
标 题 :A process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts

专利号:CN-118175999-A
优先权日:2021-10-20
标题 :Process for the preparation of 2, 7-dihydroxy-9-fluorenone useful for the synthesis of telulone and its salts

专利号:CA-3235754-A1
优先权日:2021-10-20
标 题 :A process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts

专利号:US-9029504-B2
优先权日:2009-03-12
标题 :Fluorene compound
发明人：TAKAHASHI DAISUKE
权利人:AJINOMOTO KK
摘要:Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.