CAS: 3541-37-5; Benzo[b]Thiophene-2-Carbaldehyde

上下游产品

2-甲基苯并噻吩 2-Methylbenzothiophene 1195-14-8
苯并噻吩-2-羧酸 Benzo[b]Thiophene-2-Carboxylic Acid 6314-28-9
1-苯并噻吩-2-甲醇 Benzothiophene-2-Methanol 17890-56-1
1-苯并噻吩-2-羧酸乙酯 Ethyl Benzo[b]Thiophene-2-Carboxylate 17890-55-0
N-Methoxy-N-Methylbenzo[b]Thiophene-2-Carboxamide 279226-22-1

茴香硫醚置于正丁基锂体系中,用 甲基叔丁基醚 用作溶剂,化学反应 27.0H,反应生成1-苯并噻酚-2-羧醛
参考文献:硫代苯甲醚双骨架化合物的制备和ch锂化/环化反应,可用于五元杂环
标题:硫代苯甲醚双骨架化合物的制备和ch锂化/环化反应,可用于五元杂环
摘要:报道了基于硫代苯甲醚的三锂配合物的合成,分离和x射线结构.在双重锂化策略的基础上,在温和的反应条件(室温)下开发了两种新颖的合成方法:(1)锂硫代苯甲醚与腈的反应通过[3 + 2]型方法得到苯并异噻唑,其中两种新的键形成和(2)通过[4 +1]模式由硫代苯甲醚和酰胺形成苯并噻吩,形成4个新的化学键.
Doi:10.1021/acs.Orglett.8B00850

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-7339065-B2
优先权日:2003-07-21
标题 :Design and synthesis of optimized ligands for PPAR
发明人：AVERY MITCHELL A; PERSHADSINGH HARRIHAR A
权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI
摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

专利号:US-11117893-B2
优先权日:2018-09-24
标题 :Methods for preparation of substituted pyridines and related novel compounds
发明人：WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY
权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV
摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

专利号:US-2007099969-A1
优先权日:2003-07-21
标题 :Design and synthesis of optimized ligands for ppar