CAS: 348-52-7; 1-Fluoro-2-Iodobenzene

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CAS号348-54-9 邻氟苯胺 | CAS号131049-54-2 o-potassiofluor... | CAS号1034926-54-9 bis(2-fluorophe... | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号1072-85-1 1-溴-2-氟苯 | CAS号462-06-6 氟苯 | CAS号108-95-2 苯酚 | CAS号7647-01-0 盐酸 | CAS号56-23-5 四氯化碳 | CAS号367-12-4 2-氟苯酚 | CAS号342-24-5 2-氟二苯甲酮 | CAS号443-26-5 邻氟苯甲酸乙酯 | CAS号394-46-7 2-氟苯乙烯 | CAS号346656-39-1 2-(2-氟苯基)-5,5-二... | CAS号348-54-9 邻氟苯胺 | CAS号394-35-4 邻氟苯甲酸甲酯 | CAS号321-60-8 2-氟联苯 | CAS号92-52-4 联苯 | CAS号84-15-1 邻二苯基苯

氟苯置于2,2,6,6-Tetramethylpiperidinyl-Lithium,碘体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,反应生成2-氟碘苯
参考文献:间歇式反应器中卤代芳基锂的去质子化生成和捕集
标题:间歇式反应器中卤代芳基锂的去质子化生成和捕集
摘要:公开了一种通过去质子化锂化对卤代芳烃进行区域选择性官能化的方法.生成的卤代芳基锂被捕获在带有氯化锌二胺复合物的间歇式反应器中,以提供没有芳炔形成的有机锌物质,其与亲电子试剂反应以 38-98% 的收率提供相应的产物.将该方法应用于克级卡巴佐霉素a的五步全合成,总收率为33%.
Doi:10.1021/acs.Orglett.3C00800

专利信息

专利号:US-7652137-B2
优先权日:2003-03-06
标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
发明人：GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.

专利号:US-5098602-A
优先权日:1988-05-11
标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements
发明人：HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA
权利人:NIPPON MINING CO
摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k
专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-8399680-B2
优先权日:2007-09-28
标 题:Arylamine synthesis method
发明人：TAILLEFER MARC; XIA NING
权利人:TAILLEFER MARC; XIA NING; CENTRE NAT RECH SCIENT
摘要:The invention relates to a method for preparing arylamines and, in particular, a method for preparing aniline and anilines substituted on the aromatic ring from ammonia, under easily-industrialized mild conditions with good selectivity and yields, in the presence of a catalytic system including a copper complex.

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

专利号:CN-113087691-B
优先权日:2021-03-26
标题:A method for the synthesis of chiral aryl tertiary alcohols and benzopyrans based on a kinetic resolution strategy