CAS: 33091-17-7; 1,2,3,5-Tetrachloro-4-(2,3,4,6-Tetrachlorophenyl)Benzene

该化合物是多氯代联苯(PCB)家族的成员,该家族由多氯代苯双苯分子组成,其特点是高度氯化,这大大改变了其物理和化学特性;在室温中,该化合物一般为固体,具有低挥发性和高热稳定性;由于其氯化结构,它具有疏水和脂质,导致环境和活生物体中的生物累积;已知2,2',3,3',4,4',4,6'-八氯联苯在环境中的持久性,耐降解性以及潜在的毒性影响,包括内分泌干扰和致癌性;由于环境和健康方面的考虑,其使用受到很大限制或禁止.

英文名称1,2,3,5-Tetrachloro-4-(2,3,4,6-Tetrachlorophenyl)Benzene
中文名称2,2',3,3',4,4',6,6'-八氯联苯
IUPAC名称1,2,3,5-tetrachloro-4-(2,3,4,6-tetrachlorophenyl)benzene
其它别名1,1'-Biphenyl,2,2',3,3',4,4',6,6'-°Ctachloro-, (?à)-; Biphenyl, 2,2',3,3',4,4',6,6'-°Ctachloro- (8CI); (?à)-2,2',3,3',4,4',6,6'-°Ctachloro-1,1'-biphenyl; 2,2',3,3',4,4',6,6'-°Ctachloro-1,1'-biphenyl; 2,2',3,3',4,4',6,6'-°Ctachlorobiphenyl; 2,3,4,6,2',3',4',6'-°Ctachlorobiphenyl
CAS编号33091-17-7
MFCD编号:MFCD00792627
FDA UNII编号:600RQQ4YVA
分子式:C12H2Cl8分子量:429.77
产品CID: 1324426
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: YPDBBDKYNWRFMF-UHFFFAOYSA-N
1S/C12H2Cl8/c13-3-1-5(15)9(17)11(19)7(3)8-4(14)2-6(16)10(18)12(8)20/h1-2H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,3,5-tetrachlorobenzene 2,3,4,6-tetrachloroaniline

合成工艺路线路线简述

📜1,2,3,5-四氯苯,2,3,4,6-四氯苯胺置于亚硝酸异戊酯体系中,化学反应生成2,2',3,3',4,4',6,6'-八氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
Doi:10.1016/0045-6535(95)00140-4