CAS: 330793-45-8; (4-(Phenylcarbamoyl)Phenyl)Boronic Acid

上下游产品

4-carboxyphenylboronic acid aniline n-butyllithium 1-phenyl-4-bromo-2-methoxybenzamideN1-phenyl-4-bromo-2-methoxybenzamide

📜4-羧基苯硼酸,苯胺置于(Benzotriazo-1-Yloxy)Tris(Dimethylamino)Phosphonium Hexafluorophosphate体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 4-苯基甲酰氨苯基硼酸
参考文献:从芳基脲到联芳基酰胺再到氨基喹唑啉:发现新型有效的trpv1拮抗剂.
标题:从芳基脲到联芳基酰胺再到氨基喹唑啉:发现新型有效的trpv1拮抗剂.
摘要:铅vr1拮抗剂1中芳基环的哌嗪生物等位取代导致了联芳基酰胺系列的产生.b环sar的发展导致构象受限的类似物70.所得氨基喹唑啉70代表一种新型vr1拮抗剂,与先导系列的类似化合物相比,具有更高的体外效价和口服生物利用度.
DOI:10.1016/j.Bmcl.2006.07.010

专利信息

专利号:US-6919382-B2
优先权日:2000-08-31
标 题 :Preparation and uses of conjugated solid supports for boronic acids
发明人：HALL DENNIS G
权利人:UNIV ALBERTA
摘要:The invention provides novel solid supports comprising dihydroxyalkyl aminoalkyl and dihydroxyalkylaminobenzyl groups, and methods for making and using them. The supports are particularly useful for immobilizing and derivatizing functionalized boronic acids for use in solid phase synthesis, such as those used in combinatorial chemistries. The compositions and methods of the invention are also useful as scavenger solid supports, e.g., in solution-phase parallel synthesis of small molecule libraries, and for use in resin-to-resin transfer reactions via phase transfer of solid supported boronic acids under both aqueous and anhydrous conditions. The methods of the invention provide convergent solid-phase synthesis of symmetrically or unsymmetrically functionalized compounds, such as biphenyl compounds. Also provided are synthesizer devices, e.g., semiautomated parallel synthesizers.