CAS: 2975-46-4; 3-(Trimethylsilyl)-2-Propynal

相似化合物

16205-84-8 5683-31-8 42201-71-8

上下游产品

三甲硅基丙炔醇 3-Trimethylsilyl-2-Propyn-1-Ol 5272-36-6

📜丙炔氧基三甲基硅烷置于正丁基锂,Pyridinium Chlorochromate体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 5.0H,反应生成3-三甲基甲硅烷基丙炔醛
参考文献:Asymmetric Synthesis Of The C3-C8Fragment Of Leucotrienes And Analogues
标题:Asymmetric Synthesis Of The C3-C8Fragment Of Leucotrienes And Analogues
摘要:利用手性亚磺酰酯的羟醛型缩合反应,实现了白三烯c3-C8片段及其类似物的非对称合成.具体而言,从(3S)-3-叔丁基二甲基硅氧基-1-(2-甲氧基乙氧基甲氧基)-5-三甲基硅基-4-戊炔出发,制备了相应的甲基(2Z,4S)-己烯酸酯,甲基(4R)-己酸酯,(2Z,4S)-和(2E,4S)-2-己烯醛衍生物.在此次研究过程中制备的几种分子被证实为合成多种天然产物的重要中间体.
Doi:10.1055/s-1991-26622

专利信息

专利号:US-5840961-A
优先权日:1996-07-12
标 题:Asymmetric synthesis of chiral beta-amiNo acids
发明人：BEHLING JAMES RICHARD; BOYS MARK LAURENCE; CAIN-JANICKI KIMBERLY JO; COLSON PIERRE-JEAN; DOUBLEDAY WENDEL WILLIAM; DURAN JOSEPH EDWARD; FARID PAYMAN N; KNABLE CARL MATTHEW; MUELLNER FRANK WALTER; NUGENT SEAN THOMAS; TOPGI RAVINDRA S
权利人:SEARLE & CO
摘要:The invention herein is directed to a process for the preparation of ethyl 3S-amino-4-pentynoate which involves treating 3-(trimethylsilyl)-2-propynal with L-phenylglycinol in toluene to produce αS- 3-(trimethylsilyl)-2-propynylidene amino!benzenethanol; reacting αS- 3-(trimethylsilyl)-2-propynylidene!amino!benzenethanol with BrZnCH 2 CO 2 t-Bu in THF/NMP to produce 1,1-dimethylethyl 3S- (2-hydroxy-1S-phenylethyl)amino!-5-(trimethylsilyl)-4-pentynoate; reacting the 1,1-dimethylethyl 3S- (2-hydroxy-1S-phenylethyl)amino!-5-(trimethylsilyl)-4-pentynoate with sodium periodate to form 1,1-dimethylethyl 3S- (phenylmethylene)amino!-5-(trimethylsilyl)-4-pentynoate; hydrolyzing 1,1-dimethylethyl 3S- (phenylmethylene)amino!-5-(trimethylsilyl)-4-pentynoate to produce 1,1-dimethylethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate; transesterifying 1,1-dimethyl 3S-amino-5-(trimethylsilyl)-4-pentynoate and desilylating to produce ethyl 3S-amino-4-pentynoate.

专利号:US-2003096374-A1
优先权日:1999-01-27
标题:Synthesis of oligoketides

专利号:US-10287225-B2
优先权日:2015-05-13
标 题:Chain multiyne compound, preparation method and application thereof
发明人：XIA HAIPING; ZHUO QINGDE; LIN JIANFENG; ZHOU XIAOXI; CHEN ZHIXIN; SHAO YIFAN; ZHANG HONG; HE XUMIN
权利人:UNIV XIAMEN
摘要:The present invention relates to fields of organic chemistry and organometallic chemistry. The present invention discloses a chain multiyne compound, a preparation method thereof and an application in synthesizing a fused-ring metallacyclic compound. A structure of the chain multiyne compound in the present invention is shown as Formula I below. The present invention also provides a preparation method of the chain multiyne compound and an application thereof in a synthesis of a fused-ring metallacyclic compound. The chain multiyne compound disclosed in the present invention has multiple functional groups and the structure of the chain multiyne compound is adjustable. The chain multiyne compound can also be used to synthesize the fused-ring metallacyclic compound efficiently. The preparation method of the chain multiyne compound disclosed in the present invention is simple, which can be used to prepare the chain multiyne compound rapidly and efficiently.

专利号:WO-0044717-A2
优先权日:1999-01-27
标 题 :Synthesis of oligoketides

专利号:ZA-976138-B
优先权日:1996-07-12
标 题 :Asymmetric synthesis of chiral beta-amino acids

专利号:WO-9802410-A1
优先权日:1996-07-12
标题 :Asymetric synthesis of chiral beta-amino acids