CAS: 170141-63-6; 3'-(Trifluoromethoxy)Acetophenone

该化合物是一种有机化合物,其特征是附于丙酮苯环的三氟甲基苯环上的三氟甲基苯氧组(-OCF3),该化合物一般显示白色为脱白晶状固态,因其独特的化学特性和药物设计和合成的潜在应用,其独特的化学成分和材料科学领域往往用于研究和开发,特别是在医药化学和材料科学领域,因其独特的结构特征和潜在用途,该化合物在药物设计和合成方面可能具有可溶性,因此经常被用于研究和开发.

结构式图片

相似化合物

347194-02-9 101975-23-9 1821840-58-7

欧盟法规

ECHA物质C&L通报

上下游产品

3-(三氟甲氧基)苯甲醛 3-(Trifluoromethoxy)Benzaldehyde 52771-21-8
3-(三氟甲氧基)苯甲酸 3-(Trifluoromethoxy)Benzoic Acid 1014-81-9
3-羟基苯乙酮 3-Hydroxyacetophenone 121-71-1

合成工艺路线路线简述

    3-(三氟甲氧基)苯甲醛置于哌啶,吡啶,Iron(II) Chloride体系中,用 乙醇 用作溶剂,化学反应 25.0H,反应生成3-(三氟甲氧基)苯乙酮
    参考文献:Iron-Catalyzed Domino Decarboxylation-Oxidation Of α,β-Unsaturated Carboxylic Acids Enabled Aldehyde C-h Methylation
    标题:Iron-Catalyzed Domino Decarboxylation-Oxidation Of α,β-Unsaturated Carboxylic Acids Enabled Aldehyde C-h Methylation
    摘要:铁催化的α,β-不饱和羧酸的串联脱羧氧化反应,实现了醛的c-H甲基化,用于制备多样化的甲基酮,并可应用于复杂小分子的晚期修饰.
    Doi:10.1039/d1Cc01536B

    海关参考信息

    专利信息


    专利号:WO-9925385-A1
    优先权日:1997-11-17
    标 题:A method of increasing nucleic acid synthesis with ultrasound
    发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
    权利人:IMARX PHARMACEUTICAL CORP
    摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

    专利号:US-6005103-A
    优先权日:1993-11-19
    标题 :Pyrone derivatives as protease inhibitors and antiviral agents
    发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
    权利人:WARNER LAMBERT CO
    摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

    专利号:EP-0729465-B1
    优先权日:1993-11-19
    标 题:Pyrone derivatives as protease inhibitors and antiviral agents
    发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
    权利人:PARKE DAVIS & CO
    摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Michael J Gorczynski, Et Al. Allosteric Inhibition Of The Protein-Protein Interaction Between The Leukemia-Associated Proteins Runx1 And Cbfbeta. Chem Biol. 2007 Oct;14(10):1186-97.

    合成参考文献


    摘要:Yerien, D. E.; Barata-Vallejo, S.; Postigo, A., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 9.
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