CAS: 16732-73-3; 6-Methoxy-1H-Indole-2-Carboxylic Acid

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CAS号15050-04-1 6-甲氧基-2-吲哚羧酸乙酯 | CAS号98081-83-5 6-甲氧基-1H-吲哚-2-羧酸甲酯 | CAS号123-11-5 4-甲氧基苯甲醛; 对甲氧基苯... | CAS号98081-75-5 methyl 2-azido-... | CAS号3189-13-7 6-甲氧基吲哚 | CAS号124-38-9 二氧化碳 | CAS号2042-14-0 4-甲基-3-硝基苯酚 | CAS号17484-36-5 4-甲基-3-硝基苯甲醚 | CAS号40047-23-2 6-羟基吲哚-2-甲酸 | CAS号3189-13-7 6-甲氧基吲哚 | CAS号143702-30-1 1-(benzenesulfo... | CAS号30464-85-8 (6-甲氧基-1H-吲哚-2-基)甲醇 | CAS号30464-93-8 6-甲氧基-1H-吲哚-2-甲醛 | CAS号70555-46-3 6-甲氧基吲哚-3-甲醛 | CAS号15050-04-1 6-甲氧基-2-吲哚羧酸乙酯 | CAS号651331-51-0 6-methoxy-1-(4-... | CAS号651331-67-8 10-[6-methoxy-1... | CAS号651331-76-9 12-[6-methoxy-1...

3-甲氧基-苯肼置于sodium Acetate,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,水 用作溶剂,化学反应生成6-甲氧基吲哚-2-羧酸
参考文献:Structure-Based Design And Biological Evaluation Of Novel 2-(Indol-2-yl) Thiazole Derivatives As Xanthine Oxidase Inhibitors
标题:Structure-Based Design And Biological Evaluation Of Novel 2-(Indol-2-yl) Thiazole Derivatives As Xanthine Oxidase Inhibitors
摘要:Inhibition Of Xanthine Oxidase (Xo) Has Obviously Been A Central Concept For Controlling Hyperuricemia,Which Causes Serious And Painful Inflammatory Arthritis Disease Such As Gout. We Discovered A Series Of Novel 2-(Indol-2-yl) Thiazole Derivatives As Xo Inhibitors At The Level Of Nanomolar Activity. Structure-Guided Design Using Molecular Modeling Program (Accelrys Software Program) Provided An Excellent Basis For Optimization Of 2-(Indol-2-yl) Thiazole Compounds. Structure-Activity Relationship Indicated That Hydrophobic Alkoxy Group (Isopropoxy,Cyclopentoxy) At 5-Position And Hydrogen Binding Acceptor (No2,Cn) At 7-Position Of Indole Ring Appear As Critical Functional Groups. Among The Compounds,2-(7-Nitro-5-Isopropoxy-Indol-2-yl)-4-Methylthiazole-5-Carboxylic Acid (9M) Exhibits The Most Potent Xo Inhibitory Activity (Ic50 Value: 5.1 Nm) And The Excellent Uric Acid Lowering Activity In Potassium Oxonate Induced Hyperuricemic Rat Model. (C) 2016 Published By Elsevier Ltd.
Doi:10.1016/j.Bmcl.2015.12.055