CAS: 167072-91-5; (R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]Octa-1(6),2,4-Trien-7-yl)Methyl)(Methyl)Amino)Propyl)-7,8-Dimethoxy-1,3,4,5-Tetrahydro-2H-Benzo[d]Azepin-2-One

该化合物是复杂的有机化合物,其特征是多周期结构和各种功能组.该物质具有苯丙胺核心,是一个包含苯和环的双环的双环结构,有助于其潜在的生物活动.甲基丙烯组的存在增强了其脂性,有可能影响其药用基因特性.该化合物还含有第三级的地雷,在与生物目标(如受体或酶)的互动中可能发挥作用.其立体化学化学学,特别是7R)配置,它提出了可能影响其生物功效和受体约束性的具体空间安排.

结构式图片

相似化合物

304464-98-0 304462-60-0 1246638-08-3

物理性质

MSDS等安全信息

上下游产品

3-[3-[[[-3,4-Dimethoxybicyclo[4.2.0]Octane-1,3,5-Trien-7-Yl]Methyl]Methylamino]Propyl]-1,3,4,5-Tetrahydro-7,8-Dimethoxy-2H-3-Benzazepine-2-One 148870-59-1
N-{[(7S)-3,4-Dimethoxybicyclo[4.2.0]Octa-1,3,5-Trien-7-Yl]Methyl}-3-(7,8-Dimethoxy-2-Oxo-1,2,4,5-Tetrahydro-3H-3-Benzazepin-3-yl)-N-Methylpropanimidamide 1246638-11-8
伊伐布雷定杂质2 7,8-Dimethoxy-3-Methylaminopropyl-1,3,4,5-Tetrahydro-2H-3-Benzazepin-2-One 85175-77-5
3-(7,8-Dimethoxy-2-Oxo-1,2,4,5-Tetrahydro-3H-3-Benzazepin-3-yl)Propanal 85175-82-2
(±)-(3,4-Dimethoxybicyclo[4.2.0]Octa-1,3,5-Trien-7-yl)Methanol
(R,S)-(3,4-Dimethoxybicyclo[4.2.0]Octa-1,3,5-Trien-7-yl)Methyl Methanesulphonate 1239343-06-6

合成工艺路线路线简述

    📜N-{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-Trien-7-Yl]Methyl}-3-(7,8-Dimethoxy-2-Oxo-1,2,4,5-Tetrahydro-3H-3-Benzazepin-3-yl)-N-Methylpropanimidamide置于sodium Tetrahydroborate,Sodium Hydroxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 0.25H,反应生成2H-3-苯并吖庚英-2-酮,3-[3-[[[(7R)-3,4-二甲氧基二环[4.2.0]辛-1,3,5-三烯-7-基]甲基]甲基氨基]丙基]-1,3,4,5-四氢-7,8-二甲氧基-
    参考文献:Process For The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
    标题:Process For The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
    摘要:合成ivabradine(化学式i)及其与药用可接受酸形成的盐的过程.

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    专利信息


    专利号:US-8097720-B2
    优先权日:2008-12-24
    标题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE
    权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; LAB SERVER
    摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

    专利号:US-8415468-B2
    优先权日:2009-02-04
    标题 :Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
    发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE
    权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; SERVIER LAB
    摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

    专利号:US-2011294999-A1
    优先权日:2009-02-04
    标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

    专利号:US-2010160628-A1
    优先权日:2008-12-24
    标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

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    主要参考文献

    参考标题:Process For The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
    摘要:Process For The Synthesis Of Ivabradine Of Formula (I): And Addition Salts Thereof With A Pharmaceutically Acceptable Acid.
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