CAS: 115457-83-5; Methyl 6-O-(N-Heptylcarbamoyl)-α-D-Glucopyranoside

该化合物是甘蔗糖的胶质衍生物,其特点是:在葡萄糖环的6个位置上存在一个七基碳乙酰集团;该化合物的特征是附于厌食碳的甲基组,该组会影响其溶解性和再活性;七基氯乙胺基会增强亲脂性,有可能影响其生物活动和与细胞膜的相互作用;该结构表明,它可以参与各种生物化学过程,可能作为酶反应中的基质或抑制剂;它独特的水文哲学(苏格)和缺水性(湿度组)特性组合,可以使其在配方中作为表面活化剂或乳化剂发挥作用;此外,该化合物的稳定性,溶解性及再活力可能受诸如pH和温度等环境因素的影响.总体而言,6-O(N-乙基碳酸)-甲基-D-甘酸盐表面表面是一个具有潜在生物化学和制药用途的多用途化学实体.

结构式图片

相似化合物

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N-heptylis°Cyanate methyl-alpha-D-glucopyranoside °Ctanoyl azide methyl beta-D-glucopyranoside

合成工艺路线路线简述

    📜辛酰叠氮化物 以 吡啶,甲苯 用作溶剂,化学反应 22.0H,反应生成甲基6-O(N-庚甲酰)-α-D-葡萄糖苷
    参考文献:Chimie Des Sucres Sans Groupements Protecteurs-Ii Reactions Selectives D'Addition Du-Glucose,Du-Galactose Et De-Glycosylamines A Des Heterocumulenes
    标题:Chimie Des Sucres Sans Groupements Protecteurs-Ii Reactions Selectives D'Addition Du-Glucose,Du-Galactose Et De-Glycosylamines A Des Heterocumulenes
    摘要:
    Doi:10.1016/s0040-4020(01)85430-2

    海关参考信息

    专利信息


    专利号:US-2012190064-A1
    优先权日:2004-10-01
    标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
    发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
    权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
    摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

    专利号:US-2001049117-A1
    优先权日:1998-08-20
    标 题 :Analogs of udp-murnac peptides, assays, kits and related methods of their use
    发明人:AXELROD HELENA R; BRANSTROM ARTHUR A
    摘要:General compositions and methods for detecting Lipid I, Lipid II and peptidoglycan synthesis is disclosed. A method of screening for potential antibacterial agents is provided which requires bacterial membrane preparations or enriched enzyme preparations including at least one bacterial enzyme involved in the synthesis of Lipid I from UDP-MurNAc pentapeptide and undecaprenyl phosphate, at least one bacterial enzyme involved in the synthesis of Lipid II from Lipid I and UDP-GlcNAc and one or more bacterial enzymes involved in the further processing of Lipid II toward the downstream synthesis of peptidoglycan. The methods disclosed herein further provides a labeled UDP-MurNAc-peptide capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid I and a labeled UDP-GlcNAc capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid II. Conditions for further processing of Lipid II toward the downstream synthesis of peptidoglycan are also discribed.

    专利号:US-6600029-B1
    优先权日:1995-12-19
    标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
    发明人:SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
    权利人:UNIV MINNESOTA
    摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

    专利号:US-2003194784-A1
    优先权日:2001-04-17
    标题:DNA encoding methymycin and pikromycin
    发明人:SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
    摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

    专利号:US-6265202-B1
    优先权日:1998-06-26
    标 题 :DNA encoding methymycin and pikromycin
    发明人:SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
    权利人:UNIV MINNESOTA
    摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

    专利号:US-2009209032-A1
    优先权日:2004-10-01
    标 题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Angelo Benedetti, Et Al. Histone 2A Stimulates Glucose-6-Phosphatase Activity By Permeabilization Of Liver Microsomes. Biochem J. 2002 Oct 15;367(Pt 2):505-10.
    [参考文献]: D Plusquellec, Et Al. Synthesis And Characterization Of 6-O-(N-Heptylcarbamoyl)-Methyl-Alpha-D-Glucopyranoside, A New Surfactant For Membrane Studies. Anal Biochem. 1989 May 15;179(1):145-53.
    [参考文献]: E Chabaud, Et Al. Stabilization Of Integral Membrane Proteins In Aqueous Solution Using Fluorinated Surfactants. Biochimie. 1998 May-Jun;80(5-6):515-30.
    [参考文献]: J Ngondi-Ekome, Et Al. Study On Agglutinating Factors From Flocculent Saccharomyces Cerevisiae Strains. Biochimie. 2003 Jan-Feb;85(1-2):133-43.
    [参考文献]: Katrin Paeschke, Et Al. Pif1 Family Helicases Suppress Genome Instability At G-Quadruplex Motifs. Nature. 2013 May 23;497(7450):458-62.

    合成参考文献


    参考文献:10.1007/978-1-4419-7251-4_15
    摘要:Buxbaum E. Membrane Proteins. 2010 Oct 01. In: Biophysical Chemistry of Proteins.
    参考文献:10.1007/978-3-319-73148-3_2
    摘要:Popot J. Extracting Membrane Proteins from Their Native Environment. 2018. In: Biological and Medical Physics, Biomedical Engineering.
    参考文献:10.1007/s11746-997-0112-2
    摘要:de la Maza A, Parra JL. Changes in phospholipid bilayers caused by sodium dodecyl sulfate/nonionic surfactant mixtures. J Americ Oil Chem Soc. 1997 Jan;74(1):9–17. doi: 10.1007/s11746-997-0112-2.
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