CAS: 96-76-4; 2,4-Di-Tert-Butylphenol

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CAS号32857-07-1 2-(dimethylamin... | CAS号128-39-2 2,6-二叔丁基苯酚 | CAS号108-95-2 苯酚 | CAS号115-11-7 2-甲基丙烯 | CAS号507-19-7 溴代叔丁烷 | CAS号513-35-9 2-甲基-2-丁烯 | CAS号1014-60-4 1,3-二叔丁基苯 | CAS号507-20-0 氯代叔丁烷 | CAS号75-65-0 叔丁醇 | CAS号39117-89-0 5,7-ditert-buty... | CAS号110546-20-8 1,4-双(2-羟基-3,5-... | CAS号3602-55-9 叔丁基对苯醌 | CAS号2460-77-7 2,5-二叔丁基-1,4-苯醌 | CAS号3846-71-7 紫外线吸收剂(UV-320) | CAS号3864-99-1 紫外线吸收剂 UV-327 | CAS号37942-07-7 3,5-二叔丁基水杨醛 | CAS号32857-07-1 2-(dimethylamin... | CAS号120695-70-7 Methylimino-2,2... | CAS号120695-69-4 6,8-di-tert-but...

1,3-二叔丁基苯置于5,10,15,20-Tetra(2',6'-Dichlorophenyl)Porphyrinatoiron(Iii) Chloride 1,2,3,4,5-Pentafluoro-6-Iodosylbenzene体系中,用 甲醇,二氯甲烷,水 作为反应溶剂,化学反应 0.05H,反应生成 2,4-二叔丁基苯酚
参考文献:关于甲苯在人工 P450 模型系统中的氧化机制:苯甲醇,苯甲醛和苯酚的形成
标题:关于甲苯在人工 P450 模型系统中的氧化机制:苯甲醇,苯甲醛和苯酚的形成
摘要:采用在二氯甲烷中含有五氟碘基苯 (Pfib) 和氯化血红素 (Fetppcl8Cl) 的系统来研究使用甲苯作为 P450 酶底物的模型系统的活性.氧化产物主要为相应的苯甲醇和苯甲醛.先前报道的悬浮系统扩展到 Ch2Cl2/ch3Oh/h2O 的均质混合溶液系统,以研究苯甲醇氧化成相应的苯甲醛:与 ρ =-0.86 与 σ+ 的哈米特关系.由于在天然 P450 系统中几乎没有观测到苯甲醛,因此苯甲醛的形成似乎只是"开放"模型系统的特征.在悬浮系统中,相应的苯甲醛和苯甲醇之间的产物比率(ald/alc)约为 0.1-0.4,具体取决于所应用的取代基和条件.奇怪的是,比率(ald/alc)随着甲苯衍生物苯环上取代基的电负性而增加.悬浮的时程实验...
DOI:10.1246/bcsj.76.2353

专利信息

专利号:US-10053406-B2
优先权日:2015-10-23
标题 :Synthesis of honokiol
发明人：JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN
权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA
摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-10336703-B2
优先权日:2015-05-12
标题 :Process for the synthesis of ivacaftor and related compounds
发明人：REDDY DUMBALA SRINIVASA; NATARAJAN VASUDEVAN; JACHAK GORAKHNATH RAJARAM
权利人:COUNCIL SCIENT IND RES
摘要:The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and Ar 1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.

专利号:US-11629223-B2
优先权日:2018-01-11
标 题:Synthesis of polymers from cyclic diolides
发明人：CHEN EUGENE Y; TANG XIAOYAN
权利人:UNIV COLORADO STATE RES FOUND
摘要:Biodegradable polymers with advantageous physical and chemical properties are described, as well as methods for making such polymers. In one embodiment, a new chemical synthesis route to technologically important biodegradable poly(3-hydroxybutyrate) (P3HB) with high isotacticity and molecular weight required for a practical use is described. The new route can utilize racemic eight-membered cyclic diolide (rac-DL), meso-DL, or a rac-DL and meso-DL mixture, derived from bio-sourced dimethyl succinate, and enantiomeric (R,R)-DL and (S,S)-DL, optically resolved by metal-based catalysts. With a stereoselective racemic molecular catalyst, the ROP of rac-DL under ambient conditions produces rapidly P3HB with essentially perfect isotacticity ([mm]>99%), high crystallinity and melting temperature (T m =171° C.), as well as high molecular weight and low dispersity (M n =1.54×10 5 g/mol, Ã?=1.01).

专利号:US-8304550-B2
优先权日:2007-11-30
标题 :Process for the catalytic synthesis of diaryl ethers
发明人：COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER
权利人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER; SALTIGO GMBH
摘要:Described is a process for preparing diaryl ethers of the formula (I)n nAr—O—Ar′  (I)n n In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, n by reacting an aryl of formula (II) or a aryloxy salt of formula (III)n nAr—OH  (II)n nAr—OR  (III)n n In which Ar has the same meaning as in formula (I) and R is an alkali metal, n with an aryl or heteroaryl bromide of formula (IV)n nAr′—Br  (IV)n n In which Ar′ has the same meaning as in formula (I), n characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.