CAS: 88515-58-6; (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-Yl (1R,2R,4As,6As,6Br,8Ar,10R,11R,12Ar,12Br,14Bs)-1,10,11-Trihydroxy-1,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylate

上下游产品

Potentillanoside C 1345828-74-1
Potentillanoside A 1309589-79-4

📜Potentillanoside C置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以97.2%的收率获得产物1-O-[(2Beta,3Alpha,5Xi,9Beta,18Alpha)-2,3,19-三羟基-28-氧代乌苏-12-烯-28-基]-Beta-D-吡喃葡萄糖
参考文献:Hepatoprotective Triterpenes From Traditional Tibetan Medicine Potentilla Anserina
标题:Hepatoprotective Triterpenes From Traditional Tibetan Medicine Potentilla Anserina
摘要:A Methanol Extract From The Tuberous Roots Of Potentilla Anserina (Rosaceae) Exhibited Hepatoprotective Effects Against D-Galactosamine (D-Galn)/lipopolysaccharide-Induced Liver Injuries In Mice. Six Triterpene 28-O-Monoglucopyranosyl Esters,Potentillanosides A-F,Were Isolated From The Extract Along With 32 Known Compounds,Including 15 Triterpenes. The Structures Of Potentillanosides A-F Were Determined On The Basis Of Spectroscopic Properties And Chemical Evidence. Four Ursane-Type Triterpene 28-O-Monoglycosyl Esters,Potentillanoside A (Ic50 = 46.7 Mu M),28-O-Beta-D-Glucopyranosyl Pomolic Acid (Ic50 = 9.5-Mu M),Rosamutin (Ic50 = 35.5 Mu M),And Kaji-Ichigoside F1 (Ic50 = 14.1 Mu M),Inhibited D-Galn-Induced Cytotoxicity In Primary Cultured Mouse Hepatocytes. Among These Four Triterpenes,Potentillanoside A,Rosamutin,And Kaji-Ichigoside F1 Exhibited In Vivo Hepatoprotective Effects At Doses Of 50-100 Mg/kg,P.O. The Mode Of Action Was Ascribable To The Reduction In Cytotoxicity Caused By D-Galn. (C) 2014 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Phytochem.2014.03.002