📜九甘醇置于硫酸,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三苯基膦体系中,用 四氢呋喃,二氯甲烷,水,甲苯 作为反应溶剂,化学反应 20.17H,反应生成 O-(2-叠氮乙基)-O-[2-(二羟乙酰基-氨基)乙基]七聚乙二醇
参考文献:Process For Making Antibody-Drug Conjugates
标题:Process For Making Antibody-Drug Conjugates
摘要:The Present Disclosure Is Directed To Methods For Making Compounds Of Structural Formula (I): (I),Wherein Pg Is Defined Above Herein,Which Are Useful For Making Antibody-Drug Conjugates. The Present Disclosure Is Also Directed To Processes For Making Related Payload Compounds,Related Linker-Payload Compounds,And To Compounds That Are Useful As Synthetic Intermediates For Making The Compounds Of Formula (I).