CAS: 846549-37-9; 2-((Azido-Peg8-Carbamoyl)Methoxy)Acetic Acid

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1143516-05-5 1594986-04-5 1415800-37-1

九甘醇置于硫酸,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三苯基膦体系中,用 四氢呋喃,二氯甲烷,水,甲苯 作为反应溶剂,化学反应 20.17H,反应生成 O-(2-叠氮乙基)-O-[2-(二羟乙酰基-氨基)乙基]七聚乙二醇
参考文献:Process For Making Antibody-Drug Conjugates
标题:Process For Making Antibody-Drug Conjugates
摘要:The Present Disclosure Is Directed To Methods For Making Compounds Of Structural Formula (I): (I),Wherein Pg Is Defined Above Herein,Which Are Useful For Making Antibody-Drug Conjugates. The Present Disclosure Is Also Directed To Processes For Making Related Payload Compounds,Related Linker-Payload Compounds,And To Compounds That Are Useful As Synthetic Intermediates For Making The Compounds Of Formula (I).