CAS: 843663-18-3; 4-Cyano-3-Fluorophenylboronic Acid

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号105942-08-3 4-溴-2-氟苯腈 | CAS号5419-55-6 硼酸三异丙酯 | CAS号870238-67-8 4-氰基-3-氟苯基硼酸频哪醇酯

2-氟-4-溴苯腈置于双二甲胺基乙基醚,异丙基氯化镁,硼酸三甲酯体系中,用 四氢呋喃 作为反应溶剂,以78%的收率获得产物4-氰基-3-氟苯硼酸
参考文献:使用i-Prmgcl-双[2-(n,N-二甲基氨基)乙基]醚络合物对带有敏感官能团的芳族卤化物进行非低温i / Br-Mg交换.
标题:使用i-Prmgcl-双[2-(n,N-二甲基氨基)乙基]醚络合物对带有敏感官能团的芳族卤化物进行非低温i / Br-Mg交换.
摘要:[反应:见正文]在环境温度下,在双[2-(n,N-二甲基氨基)乙基]醚存在下,对带有敏感羧酸酯和氰基的碘代和溴代芳烃与异丙基氯化镁进行选择性卤化物-镁交换,得到相应的格氏试剂.使新形成的反应性格氏试剂与亲电子试剂如硼酸三甲酯反应,以非常好或优异的收率获得产物芳基硼酸.
DOI:10.1021/ol052704P

专利信息

专利号:US-9744252-B2
优先权日:2011-08-17
标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
权利人:PIRAMAL IMAGING SA
摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

专利号:CN-109761951-A
优先权日:2019-02-11
标题:A kind of liquid crystal compound containing dioxane structure and synthesis method thereof