专利号:US-11247977-B2 优先权日:2018-06-22 标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug 发明人:FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN 权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD 摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.
专利号:US-9908846-B2 优先权日:2014-02-21 标题:Composition, synthesis, and use of new arylsulfonyl isonitriles 发明人:FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO 权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE 摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.
专利号:EP-1105359-B1 优先权日:1998-08-21 标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions 发明人:CHATURVEDI SURENDRAKUMAR 权利人:PE CORP NY 摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.
专利号:JP-7117796-B2 优先权日:2018-06-22 标 题 :its use in the synthesis of compounds and intermediates and drug substances of Brivaracetam
专利号:US-3891691-A 优先权日:1972-02-17 标题 :Styryl dyes 发明人:GENTA GUIDO R 权利人:AMERICAN ANILINE PROD 摘要:A novel series of styryl dyes is provided through Knoevenagel synthesis of a substituted benzaldehyde and a nitrile containing an active methylene group. The novel styryl dyes of the invention are suitable for the coloration of synthetic fabrics and plastics. Excellent dyeings are provided on polyethylene terephthalate of outstanding fastness characteristics.
专利号:CN-104744378-A 优先权日:2015-02-12 标 题:Synthesis of (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonamido)pyrimidin-5-yl]acrolein method