CAS: 7605-28-9; Phenylsulfonylacetonitrile

该化合物是一种有机化合物,其特征是存在一个附属于乙酰氟基苯基的混合物,这种多用途中间体主要用于合成有机化学,以制备三环化合物,药品和农用化学.其磺酰氟组增强了反应性,使其在核生殖替代和凝聚反应中具有价值.硝酸三烯功能进一步扩大了其循环和功能组变的效用.苯并聚氟化碳在标准条件下的展览稳定性,便利了处理和储存.其定义明确的再活动性特征和与各种反应条件的兼容性使得开发新合成途径的研究人员更愿意选择它.该化合物的结构特征使得能够精确控制复杂分子构造中的反应结果.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

(phenylthio)acetonitrile sodium benzenesulfonate chloroacetonitrile Benzenesulfinic acid α-phenylsulfonyl (3,4-dioxymethylenecinnamonitrile) α-benzenesulfonyl-4-methyl-cinnamonitrile 3-(4-chlorophenyl)-2-phenylsulfonyl-2-propenenitrile α-benzenesulfonyl-2-chloro-ξ-cinnamonitrile

合成工艺路线路线简述

    📜3-Ethoxy-2-(Phenylsulfonyl)Acrylonitrile置于sodium Ethanolate体系中,用 乙醇 作为反应溶剂,化学反应生成 苯磺酰乙腈
    参考文献:Neplyuev,V.M.; Sinenko,T.A.,Journal Of Organic Chemistry Ussr (English Translation),1978,Vol. 14,P. 1811-1816
    标题:Neplyuev,V.M.; Sinenko,T.A.,Journal Of Organic Chemistry Ussr (English Translation),1978,Vol. 14,P. 1811-1816

    海关参考信息

    专利信息


    专利号:US-11247977-B2
    优先权日:2018-06-22
    标题 :Compound and use thereof in synthesis of brivaracetam intermediate and crude drug
    发明人:FENG YAN; WANG RUYONG; YE YIZHANG; ZHANG FENGSEN; GONG XUAN; WANG ZHONGHONG; KANG XINSHAN
    权利人:FUJIAN HAIXI PHARMACEUTICALS CO LTD
    摘要:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.

    专利号:US-9908846-B2
    优先权日:2014-02-21
    标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
    发明人:FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
    权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
    摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

    专利号:EP-1105359-B1
    优先权日:1998-08-21
    标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
    发明人:CHATURVEDI SURENDRAKUMAR
    权利人:PE CORP NY
    摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

    专利号:JP-7117796-B2
    优先权日:2018-06-22
    标 题 :its use in the synthesis of compounds and intermediates and drug substances of Brivaracetam

    专利号:US-3891691-A
    优先权日:1972-02-17
    标题 :Styryl dyes
    发明人:GENTA GUIDO R
    权利人:AMERICAN ANILINE PROD
    摘要:A novel series of styryl dyes is provided through Knoevenagel synthesis of a substituted benzaldehyde and a nitrile containing an active methylene group. The novel styryl dyes of the invention are suitable for the coloration of synthetic fabrics and plastics. Excellent dyeings are provided on polyethylene terephthalate of outstanding fastness characteristics.

    专利号:CN-104744378-A
    优先权日:2015-02-12
    标 题:Synthesis of (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonamido)pyrimidin-5-yl]acrolein method

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 246.
    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 189.
    摘要:Mase, N., Science of Synthesis Knowledge Updates, (2013) 3, 329.
    摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 330.
    摘要:Wu, Y.; Wang, Jun; Kwong, F. Y., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 639.
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