CAS: 73724-46-6; Fmoc-Ser-Obzl

相似化合物

116861-26-8 141527-78-8 59524-02-6

上下游产品

L-serine benzyl ester N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide L-serine benzyl ester hydr°Chloride (fluorenylmethoxy)carbonyl chloridebenzyl-N-(fluorenylmethyloxycarbonyl)-O-(2,3,4,6-tetra-O-benzoyl β-D-glucopyranosyl) L-serinate benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate -L-serine benzyl esterFm°C-O-3,4,6-tri-O-benzyl-2-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-β-D-mannopyranosyl-L-serine benzyl ester -L-serine benzyl esterFm°C-O-3,4,6-tri-O-benzyl-2-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-α-D-mannopyranosyl-L-serine benzyl ester

📜9-芴甲基-N-琥珀酰亚胺基碳酸酯置于sodium Carbonate,Caesium Carbonate体系中,用 1,4-二氧六环,甲醇,水 作为反应溶剂,化学反应 0.25H,反应生成 Fmoc-O-苄基-L-丝氨酸
参考文献:Influence Of Steric Parameters On The Synthesis Of Tetramates From α-Amino-β-Alkoxy-Esters And Ph3Pcco
标题:Influence Of Steric Parameters On The Synthesis Of Tetramates From α-Amino-β-Alkoxy-Esters And Ph3Pcco
摘要:Alpha-Aminoesters React With Ph3Pcco In A Domino Addition-Wittig Cyclization Sequence Affording Enantiomerically Pure Tetramates. In The Case Of Beta-Oxo Functionalized Alpha-Aminoesters,E.G.,Esters Of Serine,Threonine Or Beta-Hydroxyornithine The Yields Of This Reaction Depend Heavily On The Bulkiness Of The Beta-Or Group And On The Configuration Of Beta-Carbon Atom C-3. Smaller Residues And 2R/3R-Configured Aminoesters Give Better Yields. The Alkoxycarbonyl Group Of The Ester Moiety And The Residue On The N-Atom Are Less Important. These Findings Can Be Accounted For By Assuming An Early Puckered Transition State For The Intramolecular Ring-Closing Wittig Reaction. The Addition Of Sub-Stoichiometric Amounts Of Benzoic Acid Or N-Hydroxysuccinimide (For Acid-Sensitive Compounds) Is Advantageous In Some Cases As It Accelerates The Formation Of The Intermediate Amide Ylides. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2011.10.099

专利信息

专利号:US-7160856-B2
优先权日:1997-04-16
标 题 :α-O-linked glycoconjugates, methods of preparation and uses thereof
发明人：DANISHEFSKY SAMUEL J; SAMES DALIBOR; HINTERMANN SAMUEL; CHEN XIAO TAO; SCHWARZ JACOB B; GLUNZ PETER; RAGUPATHI GOVINDASWAMI; LIVINGSTON PHILIP O; KUDUK SCOTT; WILLIAMS LAWRENCE
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides novel alpha-O-linked glycoconjugates such as alpha-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the alpha-O-linked glycoconjugates.

专利号:US-7550146-B2
优先权日:1997-04-16
标 题 :Glycopeptide conjugates and uses thereof
发明人：DANISHEFSKY SAMUEL J; SAMES DALIBOR; HINTERMANN SAMUEL; GLUNZ PETER; RAGUPATHI GOVINDASWAMI; LIVINGSTON PHILIP O; LLOYD KENNETH O; KUDRYASHOV VALERY
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the glycoconjugates of the invention.