CAS: 610-72-0; 2,5-Dimethylbenzoic Acid

上下游产品

phosgene 4-tolylmagnesium chloride diethyl ether methylammonium carbonate 1-(2,5-dimethylphenyl)-1-ethanone 2,5-dimethylbenzoyl chloride optically inactive 2.5-dimethyl-cyclohexane-carboxylic acid 4-methyl isophthalic acid

2,5-二甲基苯甲醇置于n-Methylpyrrolidine-2-One Hydrotribromide,双氧水体系中,用 乙腈 作为反应溶剂,化学反应生成 2,5-二甲基苯甲酸
参考文献:N-甲基吡咯烷-2-酮氢三溴化物催化h2O2氧化醇和vic-二醇
标题:N-甲基吡咯烷-2-酮氢三溴化物催化h2O2氧化醇和vic-二醇
摘要:多种仲醇,1,2-二醇和伯醇在催化量的 N-存在下,在回流的乙腈中,用 30% 过氧化氢水溶液以优异的产率选择性氧化为相应的酮,1,2-二酮和醛.甲基吡咯烷-2-一氢三溴化物 (Mpht).(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2006)
DOI:10.1002/ejoc.200500758

专利信息

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-9938278-B2
优先权日:2014-12-17
标题 :FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KREMOSER CLAUS; KINZEL OLAF; BLOMGREN PETER A; CURRIE KEVIN S; KROPF JEFFREY E; SCHMITT AARON C; WATKINS WILLIAM J; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-9820979-B2
优先权日:2011-07-13
标 题:FXR (NR1H4) binding and activity modulating compounds
发明人：KINZEL OLAF; STEENECK CHRISTOPH; KREMOSER CLAUS
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-9777013-B2
优先权日:2013-08-14
标题 :Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
发明人：NICOLAOU KYRIACOS C; LU MIN; MANDAL DEBASHIS; GANGWAR SANJEEV; CHOWDARI NAIDU S; POUDEL YAM B
权利人:UNIV RICE WILLIAM M; BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.