二甲基环已酮置于二溴丙二酸二乙酯体系中,化学反应 48.0H,以96%的收率获得产物2,6-二甲基苯酚 参考文献:Coumbarides; Dingjan; Eames,Journal Of Chemical Research-Part S,2000,# 7,P. 328-329 标题:Coumbarides; Dingjan; Eames,Journal Of Chemical Research-Part S,2000,# 7,P. 328-329
专利号:US-12291596-B2 优先权日:2018-11-30 标 题 :Radical cascade-enabled synthesis of precision polymers with complex main-chain structures 发明人:NIU JIA; HUANG HANCHU; WANG WENQI 权利人:THE TRUSTEES OF BOSTON COLLEGE 摘要:Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-6339131-B1 优先权日:1999-12-06 标题 :Synthesis of poly (arylene ether)-poly(organosiloxane) copolymers 发明人:CELLA JAMES A; LISKA JURAJ; ULERY VICTORIA L; YEAGER GARY W; NYE SUSAN ADAMS; GUO HUA; SINGH NAVJOT 权利人:GEN ELECTRIC 摘要:A method comprising n (a) synthesis of a poly(arylene ether) having the structure (1) n wherein m is an integer having an average value in the range from about 3 to about 300; n (b) solution functionalization of polymer (1) to form functionalized poly(arylene ether) having the structure (2) n wherein X is a reactive functional group selected from the group consisting of anhydride, hydroxyl, epoxy, carboxyl, —R 1 OH, R 1 CO 2 R 2 , —R 1 CH 2 â•?CH 2 , or vinyl, wherein R 1 is a primary or secondary divalent alkyl or haloalky group having from 1 to 20 carbons, or an aryl group and R 2 is a primary or secondary alkyl group having from 1 to 10 carbons; and Q 4 is hydrogen, X, or a mixture thereof; n (c) reaction of functionalized poly(arylene ether) (2) with a poly(organosiloxane) having structure (3): n wherein x is zero or one and Y is a functional group reactive with X, selected from the group consisting of —OH, —CH 2 â•?CH 2 , epoxy, amino, carboxy, —C(O)CH 2 OH, or hydrogen, to form a poly(arylene ether)-poly(siloxane) copolymer, wherein the functionalization is in solution, and copolymer synthesis and isolation are effected by first solution nd then melt copolymerization.
专利号:US-11186678-B2 优先权日:2018-11-30 标 题 :Radical cascade-enabled synthesis of precision polymers with complex main-chain structures 发明人:NIU JIA; HUANG HANCHU; WANG WENQI 权利人:TRUSTEES BOSTON COLLEGE 摘要:Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
专利号:US-5914431-A 优先权日:1996-09-23 标 题 :Cocatalysts for the synthesis of bisphenols 发明人:FENNHOFF GERHARD 权利人:BAYER AG 摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones using concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion pair bond to a matrix that is insoluble in the reaction medium.
专利号:US-4922015-A 优先权日:1987-04-08 标 题:Synthesis of peptide amides by means of a solid phase method using acid-labile anchoring groups 发明人:BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER 权利人:HOECHST AG 摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl or optionally substituted (C 6 -C 14 )-aryl, R 2 denotes hydrogen or an amino acid residue which is protected by an amino protective group which can be cleaved off with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or -O-(CH 2 ) n -COOH (with n=1 to 6), one of these radicals being -O-(CH 2 ) n -COOH. A process for the preparation thereof and the synthesis of peptide amides by means of a solid phase method using these new compounds (spacers) are described.
参考文献:10.1007/s00774-011-0291-7 摘要:Burt-Pichat B, Follet H, Toulemonde G, Arlot M, Delmas P, Chapurlat R. Methodological approach for the detection of both microdamage and fluorochrome labels in ewe bone and human trabecular bone. Journal of Bone and Mineral Metabolism. 2011 Jul 13;29(6):756–64. doi: 10.1007/s00774-011-0291-7.