专利号:US-4355165-A 优先权日:1978-07-24 标题 :Amino-functionalized phthalhydrazide intermediates 发明人:BOGUSLASKI ROBERT C; CARRICO ROBERT J; CHRISTNER JAMES E 权利人:MILES LAB 摘要:Amino-functionalized phthalhydrazide intermediates of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R 8 is ##STR2## wherein n=1-3. The compounds are intermediates in the synthesis of chemiluminescent-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
专利号:US-4363759-A 优先权日:1978-04-10 标题 :Chemiluminescent-labeled haptens and antigens 发明人:BOGUSLASKI ROBERT C; CARRICO ROBERT J; CHRISTNER JAMES E 权利人:MILES LAB 摘要:Chemiluminescent-labeled conjugates of the formula: wherein one of R1 and R2 is hydrogen and the other is -NR3R4; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R4 is wherein n=1-3 and L(CO- is the ligand or analog bound through an amide bond. Intermediates produced in the synthesis of such conjugates are also disclosed.
专利号:US-4226993-A 优先权日:1978-07-24 标题:Amino-functionalized phthalhydrazides 发明人:BUCKLER ROBERT T; SCHROEDER HARTMUT R 权利人:MILES LAB 摘要:Amino-functionalized phthalhydrazides of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R 8 is n n H.sub.2 N--CH.sub.2).sub.n n n wherein n=2-8. The compounds are intermediates in the synthesis of chemiluminescent phthalhydrazide-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
专利号:US-4331808-A 优先权日:1978-07-24 标题:Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled haptens 发明人:BUCKLER ROBERT T; SCHROEDER HARTMUT R 权利人:MILES LAB 摘要:Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms, n=2-6 and L(CO-- is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an antibody, or a binding analog thereof, bound through an amide bond; and intermediates produced in the synthesis of such conjugates. The labeled conjugates are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
专利号:US-4238395-A 优先权日:1978-07-24 标题:Dimethyl 7-[ω-N-(phthalimido)alkyl]aminonaphthalene-1,2-dicarboxylates 发明人:BUCKLER ROBERT T; SCHROEDER HARTMUT R 权利人:MILES LAB 摘要:-Dimethyl 7-[ω-N-(phthalimido)alkyl]aminonaphthalene -1,2-dicarboxylates of the formula: ##STR1## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms and n=2-6. The compounds are intermediates in the synthesis of chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.
专利号:US-4225485-A 优先权日:1978-07-24 标 题:Chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled polypeptides and proteins 发明人:BUCKLER ROBERT T; SCHROEDER HARTMUT R 权利人:MILES LAB 摘要:Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms, n=2-6 and L(CO-- is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an antibody, or a binding analog thereof, bound through an amide bond; and intermediates produced in the synthesis of such conjugates. The labeled conjugates are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.