CAS: 556-88-7; 2-Nitroguanidine

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CAS号506-93-4 硝酸胍 | CAS号594-14-9 硫酸胍 | CAS号593-84-0 硫氰酸胍 | CAS号62154-79-4 Nitroguanylazide | CAS号674-81-7 亚硝基胍 | CAS号7664-38-2 磷酸 | CAS号18264-75-0 1-氨基-3-硝基胍 | CAS号7697-37-2 硝酸 | CAS号113-00-8 guanidine | CAS号593-85-1 碳酸胍 | CAS号4245-76-5 甲基硝基胍 | CAS号101250-97-9 1,2-dimethyl-3-... | CAS号18264-75-0 1-氨基-3-硝基胍 | CAS号420-04-2 氰胺 | CAS号79-17-4 氨基胍盐酸盐 | CAS号674-81-7 亚硝基胍 | CAS号5465-96-3 2-硝基亚氨基咪唑烷 | CAS号7664-41-7 氨 | CAS号10034-93-2 硫酸肼

亚硝基胍置于potassium Permanganate,硝酸体系中,化学反应生成 硝基胍
参考文献:Thiele,Justus Liebigs Annalen Der Chemie,1893,Vol. 273,P. 136
标题:Thiele,Justus Liebigs Annalen Der Chemie,1893,Vol. 273,P. 136

专利信息

专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-4704450-A
优先权日:1983-02-21
标 题 :Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4581168-A
优先权日:1983-02-21
标题:Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4152322-A
优先权日:1978-04-28
标 题 :Process for selective reduction of nitroarginyl peptides with titanium (iii)
发明人：FREIDINGER ROGER M
权利人:MERCK & CO INC
摘要:Nitroarginyl peptides are selectively reduced to the corresponding arginyl peptides by titanium (III). The nitro protecting group which is labile toward nucleophilic reagents is retained through part of a synthesis and selectively removed prior to treatment with nucleophiles such as hydrazine and ammonia. The selectivity of titanium (III) for removal of the nitro functionality increases the flexibility of this protecting group in the synthesis of arginyl peptides. The present novel process is useful in the synthesis of medicinal peptides such as molluscan cardiac stimulant H-Phe-Met-Arg-Phe-NH 2 .

专利号:WO-2025037082-A1
优先权日:2023-08-11
标题:Improved flow synthesis
发明人：MCWHIR NAIL; KENNEDY STUART; JONES CHRISTOPHER; DIDSBURY MATTHEW PAUL; JUBB DANIEL; THOMAS SIMON DAVID; MURRAY IAN EWART PATTERSON
权利人:BAE SYSTEMS PLC
摘要:The invention relates to a method for the flow synthesis manufacture of energetic materials with a two stage-temperature reactor. There is provided a flow reactor for the synthesis of energetic materials, comprising; i. a first input flow reagent, and a second input flow reagent ii. a flow reactor, comprising at least two temperature zones within the reactor. (Formula (I))