CAS: 534-26-9; 2-Methyl-4,5-Dihydro-1H-Imidazole

该化合物是一种杂交有机化合物,其特点是五人环状结构,内含两个氮原子;它是伊米达佐尔的衍生物,在第二个碳位置上有一个甲基组;该化合物一般是无色的,淡黄色液体,有独特的类似矿的气味. 2-甲基乙基碘乙醇因其基本性而闻名,并且由于氮原子的存在,可参与质子反应,而成为薄弱的基底;它溶于水和各种有机溶剂,可适用于不同用途;该化合物经常用于表面活性剂,腐蚀抑制剂合成和作为有机合成的建筑块;此外,该化合物由于其生物活动,有可能在制药工业中应用.应考虑安全因素,因为它可能会在接触皮肤或眼睛时引起刺激.建议在通风良好的地区进行适当的处理和储存,以尽量减少接触.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号107-15-3 乙二胺 | CAS号75-05-8 乙腈 | CAS号871-78-3 N,N'-二乙酰乙二胺 | CAS号64-19-7 冰醋酸 | CAS号1001-53-2 |N|-乙酰乙二胺 | CAS号79-20-9 乙酸甲酯 | CAS号62-55-5 硫代乙酰胺 | CAS号4271-95-8 2-methyl-1,4,5,... | CAS号1558-82-3 氰基乙酯 | CAS号5053-43-0 2-甲基嘧啶 | CAS号54198-89-9 5-氯-2-甲基嘧啶 | CAS号95-58-9 2-氯-3-甲基吡嗪 | CAS号1792-41-2 2,5-二甲基苯并咪唑 | CAS号288-32-4 咪唑 | CAS号1092546-18-3 2-imidazolineca... | CAS号2536-18-7 2-Imidazolidino... | CAS号19522-69-1 N-丁基乙烯二胺 | CAS号4013-95-0 N1,n2-二丁基乙烷-1,2-二胺

合成工艺路线路线简述

  • 合成目标产物 2-Methyl-2-Imidazoline 主要起始原料 Acetic Acid And Ethylenediamine
  • (文献来源)合成步骤主要原料 Acetic Acid 和 Ethylenediamine
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于盐酸体系中,化学反应生成 2-甲基咪唑啉
参考文献:Phillips,Journal Of The Chemical Society,1928,P. 2395
标题:Phillips,Journal Of The Chemical Society,1928,P. 2395

海关参考信息

专利信息


专利号:US-8309740-B2
优先权日:2008-05-13
标题 :One-pot synthesis of fluorinated ionic liquids
发明人:LEE HYUN JOO; SUH DONG JIN; AHN BYOUNG SUNG; KIM HONG GON; KIM CHANG SOO; KIM HOON SIK
权利人:LEE HYUN JOO; SUH DONG JIN; AHN BYOUNG SUNG; KIM HONG GON; KIM CHANG SOO; KIM HOON SIK; KOREA INST SCI & TECH
摘要:The present invention relates to a method for one-pot synthesis of ionic liquid with fluoroalkyl group, more particularly to a method for one-pot synthesis of ionic liquid with fluoroalkyl group represented by the following Chemical Formula 1 by adding and reacting a nitrogen-containing compound, a Brønsted acid of the formula YH and a fluoroolefin compound of the formula CFR 1 â•?CR 2 R 3 in a single reactor: n n n n n n n n n n wherein n nrepresents a nitrogen-containing compound; Y − represents an anion of the Brønsted acid; and R 1 , R 2 and R 3 , which may be same or different, represent hydrogen, fluorine, C 1 -C 10 alkyl or C 1 -C 10 fluoroalkyl having from 1 to 23 fluorine atoms.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人:HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-2025282813-A1
优先权日:2021-04-09
标 题 :Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
发明人:OKADA YOHEI; SUZUKI HIDEAKI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the point of attachment to an oxygen atom of a hydroxyl moiety of the nucleoside, the nucleotide, the oligonucleotide, or of the conjugate of a nucleoside, a nucleotide or an oligonucleotide to be protected; c is 0 or 1; a is an integer of 1 to 12; R3 is H; R5 is O—R6 or H, where R6 is a C8-C40 aliphatic hydrocarbon group; each of R4 is independently O—R6, where R6 is at each occurrence independently a C8-C40 aliphatic hydrocarbon group; b is 1 to 3; with the proviso that if b is 1, at least one of R3 and R5 is not H; and with the further proviso that the sum of all carbon atoms contained in the R3, R4, and R5 moieties present is larger than 23 and smaller than 200.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人:XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-6469065-B1
优先权日:1996-02-02
标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
发明人:GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Taniguchi T, Miyauchi K, Sakaguchi Y, Yamashita S, Soma A, Tomita K, Suzuki T. Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis. Nat Chem Biol. 2018 Nov;14(11):1010-1020. doi: 10.1038/s41589-018-0119-z. Epub 2018 Aug 27. doi: 10.1093/jb/mvx075. pii: E35. doi: 10.3390/biom7020035. Review.
4: Akkasaeng C, Tantisuwichwong N, Ngamhui NO, Roytrakul S, Jogloy S, Pathanothai A. Changes in Protein Expression in Peanut Leaves in the Response to Progressive Water Stress. Pak J Biol Sci. 2015 Jan;18(1):19-26. doi: 10.1111/mmi.13209. Epub 2015 Oct 7.
6: Sonawane KD, Sambhare SB. The influence of hypermodified nucleosides lysidine and t(6)A to recognize the AUA codon instead of AUG: a molecular dynamics simulation study. Integr Biol (Camb). 2015 Nov;7(11):1387-95. doi: 10.1039/c5ib00058k. doi: 10.1093/gbe/evv124.

合成参考文献


摘要:R. B. Martin and A. Parcell. J. Am. Chem. Soc. 83, 4830 (1961).
摘要:J. Elguero, E. Gonzalez, J.L. Imbach and R. Jacquier. Bull. Soc. Chim. France 1969, 4075.
参考文献:10.1007/bf02173005|10.1007/s004380050244
摘要:Kumar R, Small I, Maréchal-Drouard L, Akama K. Striking differences in mitochondrial tRNA import between different plant species. Molecular Genetics and Genomics. 1996 Sep;252(4):404–11. doi: 10.1007/bf02173005.
参考文献:10.1021/jo8009177
摘要:Ye G, Zhou A, Henry WP, Song Y, Chatterjee S, Beard DJ, Pittman CU. Tandem reactions of 1,3-diacid chlorides with 2-methylimidazoline and 2-methyl-1,4,5,6-tetrahydropyrimidine: one-pot synthesis of 1,8-naphthyridinetetraones. J Org Chem. 2008 Jul 04;73(13):5170–2. doi: 10.1021/jo8009177.
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