CAS: 37778-99-7; (S)-2-Phenylpropan-1-Ol

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CAS号34713-70-7 2-苯基丙醛 | CAS号6006-81-1 β-甲烯基苯乙醇 | CAS号292638-84-7 phenylene-ethylene | CAS号75-24-1 三甲基铝 | CAS号108-05-4 乙酸乙烯酯 | CAS号1123-85-9 2-苯基-1-丙醇 | CAS号201230-82-2 carbon monoxide | CAS号280559-30-0 4,4,5,5-四甲基-2-(... | CAS号10402-52-5 乙酸龙葵酯 | CAS号98-83-9 α-甲基苯乙烯 | CAS号492-37-5 2-苯基丙酸 | CAS号98-86-2 苯乙酮 | CAS号7782-24-3 (|S|)-(+)-2-苯丙酸 | CAS号7782-26-5 R-2-苯基丙酸 | CAS号93-53-8 2-苯基丙醛 | CAS号53750-06-4 3-methyl-3-phen...

2-苯基丙醛置于sulfolobus Solfataricus Alcohol Dehydrogenase-10,β-烟酰胺腺嘌呤二核苷酸体系中,用 乙醇 用作溶剂,化学反应 18.0H,以74%的收率获得(S)-2-苯基-1-丙醇
参考文献:在不对称催化中使用来自 Archael 超嗜热菌的稳健脱氢酶-动态还原动力学拆分进入 (S)-Profens
标题:在不对称催化中使用来自 Archael 超嗜热菌的稳健脱氢酶-动态还原动力学拆分进入 (S)-Profens
摘要:描述了硫叶硫菌 Adh-10(酒精脱氢酶同工酶 10)的高效异源表达系统及其在 2-芳基丙醛(profen 型)底物的动态还原动力学拆分 (Dyrkr) 中的用途.重要的是,在测试的 12 种醛中,观测到对 (S)-对映体的普遍偏好,与 Nsaid(非甾体抗炎药)萘普生,布洛芬,氟比洛芬,酮洛芬和非诺洛芬相对应的底物的 Ee 较高.据我们所知,这是第一次将来自这种硫叶菌属超嗜热菌的脱氢酶应用于不对称合成,也是第一个使用这种酶的 Dyrkr 的例子.必需的醛是由 Buchwald-Hartwig 型 Pd(0) 介导的丙酸叔丁酯的 α-芳基化产生的.然后在一个 [二异丁基叔丁氧基氢化铝锂 (Ldbba)] 或两个步骤 [lah/dess-Martin Periodinane] 中还原成醛.在 5% Etoh/磷酸盐缓冲液 (Ph 9) 中用 Ssadh 处理 Profenal 底物,在 80
Doi:10.1021/ja910778P

专利信息

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-2003050299-A1
优先权日:2001-07-16
标 题 :Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

专利号:US-2008058514-A1
优先权日:2001-07-16
标 题:Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors

专利号:US-8138353-B2
优先权日:2001-07-16
标题 :Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

专利号:US-2011003987-A1
优先权日:2001-07-16
标 题:Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors