CAS: 332360-06-2; Dilithium,Carbanide,Bromide

专利信息

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-4814347-A
优先权日:1985-07-22
标 题:Anthelmintic spiroketals and method of use
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-5157167-A
优先权日:1991-06-20
标题 :Organoboron reagents for the preparation of unsubstituted propargylic alcohols
发明人：EVANS JONATHAN C; GORALSKI CHRISTIAN T
权利人:MERRELL DOW PHARMA
摘要:The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.

专利号:US-7595418-B2
优先权日:2003-06-07
标 题:Protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid esters and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoci acid esters for the synthesizing of epothilone and epothilone derivatives and process for the production of these esters
发明人：WESTERMANN JUERGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:This invention describes protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid ester and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid ester for the synthesis of epothilones and epothilone derivatives and process for the production of these esters.

专利号:US-7501075-B2
优先权日:2004-09-06
标题:Synthesis agent containing methyllithium/lithium bromide, and process for the preparation thereof
发明人：EMMEL UTE; RITTMEYER PETER; WIETELMANN ULRICH; AUL RAINER
权利人:CHEMETALL GMBH
摘要:A synthesis agent containing methyllithium and lithium bromide is described, in which MeLi and LiBr are dissolved in a solvent of the general formula (I) n nwherein R 1 and R 2 independently of one another are H, methyl (Me) or ethyl (Et), and R 3 and R 4 are Me or Et,n nthe molar ratio of LiBr to MeLi being at least 0.7 and not more than 1.5 and the methyllithium concentration being at least 4 wt. %.