CAS: 21200-24-8; Indolmycin

上下游产品

吲哚霉素 Indolmycin 21193-77-1
(5S)-2-Amino-5-[(1R)-1-(1H-Indol-3-yl)Ethyl]-2-Oxazolin-4-One 20906-48-3
2-Amino-5-[1-(1H-Indol-3-yl)Ethyl]-2-Oxazolin-4-One 20906-46-1
Ethyl (2S,3R)-2-Hydroxy-3-(3-Indolyl)Butanoate 150131-72-9
(2S,3R)-2-Hydroxy-3-(1H-Indol-3-yl)Butanoic Acid 26622-60-6
Methyl (2S,3R)-3-(1H-Indol-3-yl)-2-Hydroxybutanoate 61521-54-8
2-Hydroxy-3-Indol-3-Yl-Butyric Acid Methyl Ester 5192-19-8

📜Methyl (2S,3R)-3-(1H-Indol-3-yl)-2-Hydroxybutanoate置于四氢呋喃,Lithium Hydroxide,3-Ethyl-2-Chlorobenzoxazolium Tetrafluoroborate,水,对甲苯磺酸,溶剂黄146,三乙胺体系中,用 四氢呋喃,1,4-二氧六环,乙醚,水,乙腈 用作溶剂,化学反应 110.0H,反应生成(-)-吲哚霉素
参考文献:吲哚霉素的不对称全合成
标题:吲哚霉素的不对称全合成
摘要:吲哚霉素的不对称全合成是通过关键中间体 α-吲哚霉素酸酯实现的.该酯是通过使用 (2R,3S)-3,4-二甲基-2-苯基全氢-1,4-氧氮杂-5 不对称合成制备的 (S)-3-(3-吲哚基) 丁酸甲酯氧化获得的,7-二酮.(2S,3R)-N-[2-Hydroxy-3-(3-Indolyl)-Butanoyl]-N'-Methylthiourea 由 α-Indolmycenicate 制备,用 2-Chlorobenzoxazolium 盐处理得到光学纯度为 93% 的吲哚霉素.
Doi:10.1246/cl.1980.163

专利信息

专利号:US-2025042888-A1
优先权日:2021-11-26
标题 :A process for the preparation of indolmycin and derivatives thereof
发明人：GULAM DASTAGER SYED; SHYAM SAID MADHUKAR; KHAN ABUJANAID; ARVIND KULKARNI AMOL
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN
摘要:The present disclosure relates to a new, simple, two step synthesis of Indolmycin and its derivatives of formula (I), in 4-5 hours. Formula (I) wherein said process comprising the step of: 10 (a) reacting indole derivative with methyl magnesium bromide in a suitable solvent at a temperature in the range of 0-30° C. followed by adding ethyl epoxy butanone in a suitable solvent at −20° C. for a period of 1-2 hrs and maintaining the obtained reaction mixture for 1 hr at −20° C. to obtain a compound; and (b) passing the compound obtained at step a), base and N-methylated quinidine 15 through solid-solid continuous flow reactor for 1 minute to obtain the compound of formula (I).

专利号:US-3901899-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an Nhaloaniline with a Beta -carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the Beta carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an Alpha -ethyl- Beta -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:WO-2012014109-A1
优先权日:2010-07-30
标题:Heterocyclic sulfonamides as inhibitors of transfer rna synthetase for use as antibacterial agents
发明人：DAS BISWAJIT; UPADHYAY DILIP J; PURNAPATRE KEDAR; GHOSH SOMA; KATOCH RITA
权利人:RANBAXY LAB LTD; DAS BISWAJIT; UPADHYAY DILIP J; PURNAPATRE KEDAR; GHOSH SOMA; KATOCH RITA
摘要:The present invention provides aromatic sulphonamides as tRNA synthetase inhibitors and process for their synthesis, pharmaceutical composition and method for treatment. Compounds disclosed can be used as antibacterial agents for the treatment or prevention of conditions caused by or contributed by aerobic and anaerobic Gram-positive pathogens, more particularly against bacterium, for example Staphylococcus, Enterococci and Streptococci . Compounds disclosed are used in particular for the treatment of skin and soft tissue infection, Formula (I).

专利号:CA-1043337-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein

专利号:CN-109867643-A
优先权日:2017-12-01
标题:A kind of polysubstituted furan derivative and its synthesis