CAS: 2117-28-4; Bis(Trimethylsilyl)Methane

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CAS号75-77-4 三甲基氯硅烷 | CAS号13170-43-9 (三甲基硅基)甲基氯化镁 | CAS号67-66-3 氯仿 | CAS号2344-80-1 氯甲基三甲基硅烷 | CAS号75-09-2 二氯甲烷 | CAS号536-74-3 苯乙炔 | CAS号18418-72-9 双(三乙氧基硅基)甲烷 | CAS号108-94-1 环己酮 | CAS号74-95-3 二溴甲烷 | CAS号420-56-4 三甲基氟硅烷 | CAS号88036-00-4 (trimethylsilyl... | CAS号1450-14-2 六甲基二硅烷 | CAS号359-63-7 N,N-双(三氟甲基)羟胺 | CAS号371-71-1 1,1-difluoro-N-... | CAS号75-77-4 三甲基氯硅烷 | CAS号75-76-3 四甲基硅烷 | CAS号64065-08-3 双(二甲基膦)甲烷

📜二(三氯甲硅烷基)甲烷 以 乙醚 用作溶剂,化学反应生成双(三甲基硅基)甲烷
参考文献:Topchiev,A. V.; Nametkin,N. S.; Shcherbakova,A. A.,Doklady Akademii Nauk Sssr,1952,Vol. 86,P. 559-560
标题:Topchiev,A. V.; Nametkin,N. S.; Shcherbakova,A. A.,Doklady Akademii Nauk Sssr,1952,Vol. 86,P. 559-560

专利信息

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-2005014954-A1
优先权日:2001-11-22
标 题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

专利号:WO-2022123336-A1
优先权日:2020-12-07
标 题 :Chromeno [4,3-b] quinoline compounds and their synthesis by using silicotungstic acid [h4siw12o40]
发明人：HEGDE SUBRAMANYA GOPAL; LOKESH KOODLUR SANNEGOWDA; SHUBHA JAYACHAMARAJAPURA PRANESH; SUSHMA NURANI VISWANATHAN; BASAVARAJU GIRISH; DANAGOUDAR ANANDA; BODA VIJAY KUMAR
权利人:HEGDE SUBRAMANYA GOPAL; LOKESH KOODLUR SANNEGOWDA
摘要:The present invention relates to the development of novel compounds of chromeno [4,3-b] quinolone derivatives. It particularly relates to the development of novel compounds of thiochromeno [4,3-b] quinolone derivatives for the treatment of coronary artery diseases, dyslipidemia, and metabolic syndrome. The present invention also relates to the first synthesis of Silicotungstic -catalyzed Aza-Diels-Alder-reactions (ADAR) with s-prenyl derivatives of α-tetralone, 4-chromanone and Thiochroman-4-one and various substituted amines to deliver cycloadducts in good yield and excellent diastereoselectivity under mild reaction conditions. The invention further relates to the method for the treatment of coronary artery diseases, dyslipidemia, and metabolic syndrome by using synthesized compounds of thiochromeno [4,3-b] quinolone derivatives. The present invention provides the use of Silicotungstic acid as Lewis acid for Aza-Diels-Alder-reactions to get a mixture of diastereomers are the first examples. In addition to its efficiency, simplicity, and mild reaction conditions, the catalyst is very cheap and only a small amount (10 mol%) is needed. Intramolecular cyclization was carried out very conveniently as a one-pot reaction starting from the S-prenyl chromene-3-carbaldehyde and arylamines without isolation of the intermediate imines.

专利号:US-8026383-B2
优先权日:2001-07-06
标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
权利人:BASF SE
摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

专利号:US-9739423-B2
优先权日:2014-06-13
标 题 :Synthesis and hydrogen storage properties of novel metal hydrides
发明人：ANTONELLI DAVID
权利人:UNIV OF SOUTH WALES COMMERCIAL SERVICES LTD
摘要:The present disclosure relates to improved processes for the preparation of metal hydrides. The present disclosure also relates to metal hydrides, e.g., metal hydrides prepared by the processes described herein, that exhibit enhanced hydrogen storage capacity when used as hydrogen storage systems.

专利号:US-7692034-B2
优先权日:2001-07-06
标题:Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; KIRNER HANS JUERG; BIENEWALD FRANK; BURKHARDT STEPHAN; STUDER MARTIN
权利人:TEVA PHARMA
摘要:The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R a and R c are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R b is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein R a and R c are each independently of the other hydrogen or a hydroxy-protecting group, and R b is a carboxy-protective group.