CAS: 19523-57-0; 2-Ethoxy-1-Naphthaldehyde

该化合物是一种专门的芳香沙丁酯,其特点是在2位置用环烷核心替换成乙氧基,在1位置用甲状腺组替换成甲状腺组.该化合物因其在有机合成中,特别是在制备药品,染料和精美化学品方面作为多用途中间体的作用而受到重视.其独特的分子结构允许在凝聚和混合反应中有选择性地反应反应,从而有利于构建复杂的乙环环框架.该环乙烷的代产物可增加有机溶剂的溶性,便于合成应用中的处理.高纯度和一贯的质量可确保研究和工业工艺的可靠性能.

结构式图片

相似化合物

2224-00-2 773874-20-7 690963-44-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

hydrogen cyanide 2-ethoxynaphthalene 4-(2-ethoxy-[1]naphthyl)-4-oxo-butyric acid N-methyl-N-phenylformamide 3-oxo-3H-benzo[f]chromene-2-carboxylic acid (2-ethoxy-[1]naphthylmethylen)-aniline 2-Ethoxy-1-naphthylformiat 2-Ethoxy-1-naphthol

合成工艺路线路线简述

    2-萘酚置于alkaline Solution体系中,化学反应生成邻乙氧基萘甲醛
    参考文献:Sachs; Brigl,Chemische Berichte,1911,Vol. 44,P. 2105
    标题:Sachs; Brigl,Chemische Berichte,1911,Vol. 44,P. 2105

    海关参考信息

    专利信息


    专利号:US-4171439-A
    优先权日:1975-04-11
    标 题 :Antibacterial analogs of isocephalosporins
    发明人:CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
    权利人:BRISTOL MYERS CO
    摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo or hydroxyl and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

    专利号:US-4171438-A
    优先权日:1975-07-23
    标 题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
    发明人:DOUGLAS JAMES L; HORNING DONALD E; MORRIS LEESON R
    权利人:BRISTOL MYERS CO
    摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is acylamino and Z represents optionally substituted C1-C6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

    专利号:US-4112230-A
    优先权日:1975-04-11
    标题 :Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents
    发明人:MENARD MARCEL; LIM GARY M F; CONWAY TERRY T
    权利人:BRISTOL MYERS CO
    摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

    专利号:US-4118566-A
    优先权日:1975-07-23
    标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
    发明人:HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
    权利人:BRISTOL MYERS CO
    摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

    专利号:US-4166906-A
    优先权日:1975-04-11
    标题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
    发明人:CONWAY TERRY T; LIM GARY M F; MENARD MARCEL
    权利人:BRISTOL MYERS CO
    摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is hydroxyl esterified with a sulfonic acid residue and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group of the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

    专利号:US-4269773-A
    优先权日:1976-04-27
    标 题:Fused oxazolidine compounds
    发明人:MITSURU YOSHIOKA; TERUJI TSUJI; YASUHIRO NISHITANI; WATARU NAGATA
    权利人:SHIONOGI & CO
    摘要:Compounds represented by the following formula prepared from 6-aminopenicillanic acid are key intermediates in a stereo-specific synthesis of 1-oxadethiacephalosporins, highly active antibiotics: +TR [wherein COA and COB each is carboxy or protected carboxy; COX is carboxy, protected carboxy, or a group of the formula -COCQ=N2 or -COCHQ-Z (in which Q is hydrogen, lower alkyl or aryl; and Z is hydrogen or a nucleophilic group); Hal is halogen; R is lower alkyl or aralkyl; and Y is hydrogen or acyl].
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    合成参考文献


    摘要:Schall, A.; Reiser, O., Science of Synthesis, (2007) 25, 609.
    摘要:Collier, S. J., Science of Synthesis, (2004) 27, 180.
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