CAS: 179321-49-4; Tert-Butyl (4-Oxocyclohexyl)Carbamate

上下游产品

trans-tert-butyl 4-hydroxycyclohexylcarbamate tert-butyl dicarbonatedi-tert-butyl dicarbonate trans-4-hydroxycyclohexylamine trans-4-amin°Cyclohexanol hydr°Chloride 3-(4-t-butoxycarbonylamin°Cyclohexylidene)-1-tetrahydropyranyloxypropane {4-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-cyclohexyl}-carbamic acid tert-butyl ester 2HF3O2*C6H11N°C2HF3O2*C6H11NO (3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester

Trans-4-Aminocyclohexanol置于草酰氯,二甲基亚砜,三乙胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-N-Boc-氨基环己酮
参考文献:构象受限的脱氧新霉素类似物.
标题:构象受限的脱氧新霉素类似物.
摘要:脱氧霉素(1B)是一种蛋白质合成抑制剂,对革兰氏阴性(gn)细菌具有活性.合成了一系列构象受限的类似物以探测其生物活性构象.确实,在蛋白质合成测定中发现某些受约束的类似物与脱氧新霉素相同或更好(1B,Ic(50)= 8.2 Microm; 44,Ic(50)= 6.6 Microm; 35E(2),Ic(50) = 1微米).然而,脱氧新霉素在体外具有最佳的全细胞抗菌活性(大肠杆菌,Mic = 4-16 Microg / Ml;肺炎克雷伯菌,Mic = 8 Microg / Ml),这表明其他因素(例如渗透)也可能对整体有贡献.细胞活性.一个新发现是,脱氧新霉素在大肠杆菌鼠类败血病模型中有效(ed(50)= 4.8 Mg / Kg),
Doi:10.1016/j.Bmcl.2004.04.036

专利信息

专利号:US-9056876-B2
优先权日:2011-09-16
标 题:Substituted 1H-pyrazolo[3′,4′,4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：CONN JEFFREY P; LINDSLEY CRAIG W; WOOD MICHAEL R; HOPKINS COREY R; SALOVICH JAMES M; MELANCON BRUCE J
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 1H-pyrazolo[3′,4′:4,5]thieno[2,3-b]pyridin-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.