CAS: 1757-42-2; 3-Methylcyclopentanone

该化合物其结构特征为环球环,配有与第三碳相连的甲基组和在环形位置之一的碳基(C=O)组(C=O),该化合物一般是一种无色液体,有独特的气味,通常被称为舒适或甜味.它溶于有机溶剂,在水中溶解度有限.3-甲基环丙酮用于各种用途,包括溶剂和其他有机化合物的合成,其特性包括相对低的沸点和中度波动性,使其在化学过程中有用.与许多有机化合物一样,在处理时应当注意安全防范措施,因为如果吸入或浸入,可能会对健康造成危害.

结构式图片

相似化合物

1120-72-5 20500-49-6 18729-48-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

hexane-2,5-diol 3-methyladipic acid (3R)-3-methylcyclohexanone 2-hydroxy-4-methyl-cyclopentanone cis-1,3-dimethylcyclopentane trans-1,3-dimethylcyclopentane methyl-cyclopentane 2,2,4-trimethylcyclopentan-1-one Ketones ( quinoline 2-bromo-2,3-dimethylbutane dimethylketene phthalic anhydride 2-hydroperoxy-2-methoxypropane acetone 2,3-dimethyl-2,3-epoxybutane 1,1-dichloro-2,2,3,3-tetramethylcyclopropane

合成工艺路线路线简述

    2,5-己二醇置于copper Oxide-Chromium Oxide Catalyst体系中,化学反应生成Dl-3-甲基环戊酮
    参考文献:Reppe,J. W.,Acetylene Chemistry S. 118
    标题:Reppe,J. W.,Acetylene Chemistry S. 118

    海关参考信息

    专利信息


    专利号:US-6133018-A
    优先权日:1997-06-02
    标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
    发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
    权利人:CELGRO
    摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

    专利号:EP-1075534-B8
    优先权日:1998-03-11
    标 题 :Improvements in the enzymatic synthesis of chiral amines
    发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
    权利人:CELGRO
    摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

    专利号:US-10239812-B2
    优先权日:2017-04-27
    标 题 :Systems and methods for synthesis of phenolics and ketones
    发明人:FEDIE RONALD LEIGH; YAN BINGWEN; MCNEFF LARRY C; GREUEL PETER G; MCNEFF CLAYTON V
    权利人:SARTEC CORP
    摘要:Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing phenolics and ketones is included. The method can specifically include forming a reaction mixture comprising nanocrystalline cellulose (NCC) and water. The method can also include contacting the reaction mixture with a metal oxide catalyst at a temperature of 350 degrees Celsius or higher and a pressure of at least about 3200 psi to form a reaction product mixture. The reaction product mixture can include at least about 20 wt. % phenolics and at least about 10 wt. % ketones as a percentage of the total mass of nanocrystalline cellulose (NCC). Other embodiments are also included herein.

    专利号:US-2006084825-A1
    优先权日:2004-10-19
    标题 :Novel method for the stereoselective synthesis of cyclic amino acids
    发明人:BRYANS JUSTIN S; BLAKEMORE DAVID C; WILLIAMS SOPHIE C
    权利人:WARNER LAMBERT CO
    摘要:The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontinâ„¢) of Formulas (I), (II), (III), and (IV) wherein R is C 1 -C 10 alkyl or C 3 -C 10 cycloalkyl and pharmaceutically acceptable salts thereof.

    专利号:EP-1237847-B1
    优先权日:1999-12-08
    标 题 :Method for the stereoselective synthesis of cyclic amino acids
    发明人:BRYANS JUSTIN STEPHEN; BLAKEMORE DAVID CLIVE; WILLIAMS SOPHIE CAROLINE
    权利人:WARNER LAMBERT CO
    摘要:The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin®) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10 alkyl or C3-C10 cycloalkyl and pharmaceutically acceptable salts thereof.

    专利号:US-8053161-B2
    优先权日:2006-09-25
    标 题 :Resist composition, resin for use in the resist composition, compound for use in the synthesis of the resin, and pattern-forming method using the resist composition
    发明人:WADA KENJI; SAEGUSA HIROSHI
    权利人:FUJIFILM CORP
    摘要:A resist composition comprises: (A) a resin capable of increasing its solubility in an alkali developer by action of an acid; (B) a compound capable of generating an acid upon irradiation with actinic ray or radiation; (C) a resin having at least one of a fluorine atom and a silicon atom; and (D) a solvent, wherein the resin (C) has a degree of molecular weight dispersion of 1.3 or less and a weight average molecular weight of 1.0×10 4 or less.
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    主要参考文献

    [参考文献]: Na Lin, Et Al. Vibronically Resolved Electronic Circular Dichroism Spectra Of (R)-(+)-3-Methylcyclopentanone: A Theoretical Study. J Phys Chem A. 2008 Dec 4;112(48):12401-11.

    合成参考文献


    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 191.
    摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 417.
    摘要:van Leeuwen, P. W. N. M., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 454.
    摘要:Watson, I. D. G.; Toste, F. D., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 292.
    摘要:Faber, K.; Hall, M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 217.
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