CAS: 151103-08-1; 4-(Difluoromethoxy)-3-Hydroxybenzaldehyde

相似化合物

1159429-52-3 913985-07-6 127842-54-0

上下游产品

metyhyl chlorodifluoroacetate 3,4-dihydroxybenzaldehyde sodium chlorodifluoroacetate Chlorodifluoromethane 3-Cyclopentyloxy-4-difluoromethoxybenzaldehyde 3,4-bis-(difluoromethoxy)-benzaldehyde 3-cyclobutoxy-4-difluoromethoxy-benzaldehyde 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(Benzyloxy)-4-(Difluoromethoxy)Benzaldehyde置于5%-Palladium/activated Carbon,氢气体系中,用 乙酸乙酯 用作溶剂,化学反应 1.0H,以43.7%的收率获得4-二氟甲氧基-3-羟基苯甲醛
参考文献:治疗肝病的药物化合物及其应用
标题:治疗肝病的药物化合物及其应用
摘要:本发明公开了一类治疗肝病的药物化合物及其应用,其具体为通式(I)所示的化合物,光学异构体或其药学上可接受的盐.本发明所提供的化合物,光学异构体或其药学上可接受的盐对肝病,特别是脂肪肝具有疗效佳和毒性低的效果,实验显示,本发明化合物对斑马鱼非酒精性脂肪肝有明显的保护作用,因此其在应用于治疗或预防肝病,特别是脂肪肝,肝纤维化或肝硬化的药物方面,具有非常好的应用前景.

专利信息

专利号:US-7511150-B2
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds
发明人：ARALDI GIAN-LUCA; RONSHEIM MELANIE; DIEP NHUT; ZHOU SHAO HONG
权利人:FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of heterocyclic compounds including N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts thereof.

专利号:US-2008009632-A1
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds

专利号:US-2009143593-A1
优先权日:2006-07-06
标 题:Synthesis of heterocyclic compounds

专利号:US-2020163913-A1
优先权日:2017-07-25
标 题 :CA-4 Antitumour Drug, Synthesis Method and Use Thereof
发明人：WU FANHONG; HUANG LEILEI; HUANG JINWEN; LI YINGZI; XIE DA; Hu meichen
权利人:SHANGHAI HUALI BIOMEDICAL CO LTD
摘要:The invention discloses CA-4 antitumour drug, their synthetic methods and applications. The CA-4 antitumour drug are obtained by introducing an alkoxy group or a fluorine-containing alkoxy group at the 4′ position of the natural product Combretastatin and modified with a functional chemical group at its 3′ position. The CA-4 derivated anti-tumor drugs of the invention have inhibitory ability on two targets related to tubulin and arylsulfatase, and can be used for anti-tumor treatment. t,?

专利号:EP-0812308-A1
优先权日:1995-01-31
标题 :Method for synthesis of aryl difluoromethyl ethers and the like

专利号:US-2009192315-A1
优先权日:2006-07-06
标题 :Synthesis of heterocyclic compounds