CAS: 14860-49-2; 1-(4-Chlorophenyl)-4-(Dimethylamino)-2,3-Dimethylbutan-2-Ol
- 英文名称1-(4-Chlorophenyl)-4-(Dimethylamino)-2,3-Dimethylbutan-2-Ol
- 中文名称氯苯胺丁醇
- IUPAC名称1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
- 其它别名Phenethylalcohol, p-chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methyl- (6CI,8CI); 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol; 2-(p-Chlorobenzyl)-3-dimethylaminomethyl-2-butanol; Clobutinol
- CAS编号14860-49-2
- EINECS号:238-926-4
- FDA UNII编号:1NY2IX043A
- 分子式:C14H22ClNO分子量:255.78
- 产品CID: 713660
- 同类组份化合物CAS14860-49-2 (free base)1215-83-4 (HCl)
- 产品分类原料药 → 呼吸系统用药 → 镇咳药
物理性质
- 沸点bp12 179-180°
- 密度1.0373 (rough estimate)
- PSA:23.47
- LogP:2.8312
- 折射率1.6330 (estimate)
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种中央作用的抗咳剂(咳嗽药) , 以前以硅酸盐等商品名称销售. 其首要机制据信包括抑制体温咳嗽中心咳嗽反应,尽管其精确分子目标与新药剂相比仍定义不清晰. 在临床研究中,典型剂量为40-60毫克(每天口服3次),表明急性和慢性咳嗽的咳嗽频率和严重程度显著下降.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2903919090-氯苯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6093805-A
优先权日:1991-01-22
标 题:Glycoside compounds and methods of synthesis
发明人：SHULL BRIAN K; TUINMAN ROELAND J; HOUSTON TODD A; KLEMKE R ERICH; KOREEDA MASATO
权利人:UNIV MICHIGAN
摘要:Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
专利号:SU-1750427-A3
优先权日:1989-08-16
标题:Method for synthesis of 1,3-oxazine derivatives or their physiologically tolerated acid-additive salts in the form of racemate or optically active antipodes
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Takahara A, Sasaki R, Nakamura M, Sendo A, Sakurai Y, Namekata I, Tanaka H. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54(6):552-9. doi: 10.1097/FJC.0b013e3181bfb17c. 66(5):1093-102. doi: 10.1124/mol.104.001065. Epub 2004 Jul 27. 69(2):481-7. doi: 10.1016/j.talanta.2005.10.018. Epub 2005 Nov 21. 189(1-3):e37-40. doi: 10.1016/j.forsciint.2009.04.021. Epub 2009 May 21. 133(4):144-6. German. doi: 10.1055/s-2008-1017490. 57(4):275-9. doi: 10.1159/000195855. 24(3):e19. doi: 10.1136/emj.2006.042903.
8: Homsi J, Walsh D, Nelson KA. Important drugs for cough in advanced cancer. Support Care Cancer. 2001 Nov;9(8):565-74. doi: 10.1007/s005200100252. 17(95):113. 27(10):2011-7. German.
合成参考文献
摘要:Hadad GM, El-Gindy A, Mahmoud WM. New validated liquid chromatographic and chemometrics-assisted UV spectroscopic methods for the determination of two multicomponent cough mixtures in syrup. J AOAC Int. 2008 Jan;91(1):39–51.
参考文献:10.1007/s00063-004-1071-0
摘要:Kardos P, Cegla U, Gillissen A, Kirsten D, Mitfessel H, Morr H, Schultze-Werninghaus G, Sitter H, Vogelmeier C, Voshaar T, Worth H, Eckardt V, Klimek L; German Respiratory Society. [The German Respiratory Society's Guideline for the Diagnosis and Treatment of Patients with Acute and Chronic Cough]. Med Klin (Munich). 2004 Aug 15;99(8):468–75. doi: 10.1007/s00063-004-1071-0.
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