CAS: 124700-40-9; 2-Fluoro-4-Iodobenzoic Acid

相似化合物

137553-42-5 699016-40-5 205750-82-9

上下游产品

CAS号39998-81-7 2-氟-4-碘甲苯 | CAS号124-38-9 二氧化碳 | CAS号147808-02-4 2,5-二碘氟苯 | CAS号462-06-6 氟苯 | CAS号1121-86-4 3-氟碘苯 | CAS号348-52-7 邻氟碘苯 | CAS号501433-02-9 1-fluoro-2,3-di... | CAS号204257-72-7 2-氟-4-碘苯甲酸甲酯 | CAS号205750-82-9 2-氟代-4-碘苯甲酸乙酯

2-氟碘苯置于2,2,6,6-Tetramethylpiperidinyl-Lithium,碘,异丙基氯化镁,Lithium Diisopropyl Amide体系中,用 四氢呋喃,乙醚,正己烷 用作溶剂,化学反应生成2-氟-4-碘苯甲酸
参考文献:The Basicity Gradient-Driven Migration Of Iodine: Conferring Regioflexibility On The Substitution Of Fluoroarenes
标题:The Basicity Gradient-Driven Migration Of Iodine: Conferring Regioflexibility On The Substitution Of Fluoroarenes
摘要:
Doi:10.1002/1099-0690(200210)2002:19<3351::Aid-Ejoc3351>3.0.Co;2-I

专利信息

专利号:WO-2020248279-A1
优先权日:2019-06-14
标 题 :Continuous synthesis method for substituted benzoate organic matter
发明人：HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.