以 Neat (No Solvent,Solid Phase) 用作溶剂,化学反应生成氯化钬 参考文献:Hake,D.; Urland,W.,Zeitschrift Fur Anorganische Und Allgemeine Chemie 标题:Hake,D.; Urland,W.,Zeitschrift Fur Anorganische Und Allgemeine Chemie
专利信息
专利号:US-11926589-B2 优先权日:2019-07-09 标 题 :Process for the synthesis of non-racemic cyclohexenes 发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND 权利人:BASF CORP; CALIFORNIA INST OF TECHN 摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.
专利号:US-2025082793-A1 优先权日:2021-11-09 标 题 :Macrocyclic compounds and methods of making the same 发明人:CLEATOR EDWARD; MATON WILLIAM MARC; SALTER RHYS 权利人:JANSSEN BIOTECH INC 摘要:The present invention is directed to the preparation of key intermediates and synthesis of compounds (macrocyclic compounds) and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof.
专利号:CN-1721418-A 优先权日:2005-06-22 标题:Method for catalytic synthesis of lactide from lactic acid
专利号:US-2022267247-A1 优先权日:2019-07-09 标题:Process for the synthesis of non-racemic cyclohexenes
专利号:CN-100417651-C 优先权日:2005-06-22 标 题:Method for catalytic synthesis of lactide from lactic acid
专利号:EP-3997082-A1 优先权日:2019-07-09 标 题 :Process for the synthesis of non-racemic cyclohexenes
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合成参考文献
参考文献:10.1007/s002590050440 摘要:Nijsen JFW, Zonnenberg BA, Woittiez JRW, Rook DW, Swildens-van Woudenberg IA, van Rijk PP, van het Schip AD. Holmium-166 poly lactic acid microspheres applicable for intra-arterial radionuclide therapy of hepatic malignancies: effects of preparation and neutron activation techniques. European Journal of Nuclear Medicine and Molecular Imaging. 1999 Jun 23;26(7):699–704. doi: 10.1007/s002590050440. 参考文献:10.1007/978-1-4939-6646-2_24 摘要:Hargrove D, Lu X. Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy. Methods Mol Biol. 2017;1530():379–89. doi: 10.1007/978-1-4939-6646-2_24.