CAS: 83-98-7; N,N-Dimethyl-2-(Phenyl(O-Tolyl)Methoxy)Ethan-1-Amine

上下游产品

CAS号29215-00-7 奥芬那君-D3-N-氧化物 | CAS号108-01-0 2-(二甲基氨基)乙醇 | CAS号41870-52-4 2-甲基二苯甲基氯化物 | CAS号29215-00-7 奥芬那君-D3-N-氧化物

📜N,N-二甲基-2-[(O-甲基-Alpha-苯基苄基)氧基]乙胺 N-氧化物置于sodium Tetrahydroborate体系中,用 水 作为反应溶剂,以90%的收率获得产物邻甲苯海明
参考文献:A Chemoselective Deoxygenation Of N-Oxides By Sodium Borohydride-raney Nickel In Water
标题:A Chemoselective Deoxygenation Of N-Oxides By Sodium Borohydride-raney Nickel In Water
摘要:A Simple And Convenient Protocol For Deoxygenation Of Aliphatic And Aromatic N-Oxides To The Corresponding Amines In Good To Excellent Yield Using Sodium Borohydride-Raney Nickel In Water Is Reported. Other Functional Moieties Such As Alkenes,Halides,Ethers,And Amides Are Unaffected Under The Present Reaction Condition. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2010.08.045

专利信息

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:US-7300639-B2
优先权日:2002-12-03
标 题:Process for removing metals from liquids
发明人：LIU WANSHENG
权利人:BRISTOL MYERS SQUIBB CO
摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2024123815-A1
优先权日:2022-12-06
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels