CAS: 771-99-3; 4-Phenylpiperidine

该化合物是一种有机化合物,其特征是管状环,即六人饱和含氮的乙型环,以苯基组替代4级组;该化合物一般是无色的,可粉黄液或固体,视其纯度和形态而定;其分子式为C13H17N,分子重量约为189.28克/摩尔. 4-苯基丙基丙胺因其...

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CAS号38025-45-5 1-苄基-1,2,3,6-四氢... | CAS号123387-49-5 4-苯基-1-哌啶羧酸叔丁酯 | CAS号43064-12-6 4-苯基-1,2,3,6-四氢吡啶盐酸盐 | CAS号84473-59-6 1,2,3,4-tetrahy... | CAS号939-23-1 4-苯基吡啶 | CAS号51304-58-6 4-氰基-4-苯基哌嗪 | CAS号10338-69-9 4-苯基-1,2,3,6-四氢吡啶 | CAS号14149-31-6 4-苯基哌啶-2,6-二酮 | CAS号62143-51-5 1-benzyl-4-phen... | CAS号15037-36-2 4-苯基-1-哌啶丙醇 | CAS号80980-89-8 4-(4-溴苯基)哌啶 | CAS号31414-54-7 4-phenyl-1-prop... | CAS号14446-73-2 4-Cyclohexylpip... | CAS号136534-70-8 4-phenyl-1-(4-p... | CAS号26905-03-3 4-(4-硝基苯基)哌啶 | CAS号1254977-87-1 JNJ-42153605 | CAS号120447-45-2 4-(2,4-dinitrop... | CAS号16168-22-2 4-phenylpiperid... | CAS号774-52-7 1-甲基-4-苯基哌啶

合成工艺路线路线简述

    4-苯基哌啶-2,6-二酮置于1,4-二氧六环,Copper Oxide-Chromium Oxide体系中,250.0 °C,39.22 Mpa 条件下,反应生成 4-苯基哌啶
    参考文献:Paden; Adkins,Journal Of The American Chemical Society,1936,Vol. 58,P. 2493
    标题:Paden; Adkins,Journal Of The American Chemical Society,1936,Vol. 58,P. 2493

    海关参考信息

    专利信息


    专利号:US-9029547-B1
    优先权日:2013-12-07
    标 题 :Synthesis of 4-aryl 4-acyl piperidine, its salts and analogs using indium metal
    发明人:MAJEED MUHAMMED; RAMANUJAM RAJENDRAN; NAGABHUSHANAM KALYANAM
    权利人:MAJEED MUHAMMED; RAMANUJAM RAJENDRAN; NAGABHUSHANAM KALYANAM
    摘要:A novel process for the synthesis of 4-aryl 4-acyl piperidine derivatives using indium metal is described. Specifically, a novel process for the synthesis of 4-acetyl 4-phenyl piperidine and its salts using indium metal is described. This divisional application is specifically drawn to compounds 4-aryl 1,4-diacyl piperidine and 1,4 diacetyl 4-phenyl piperidine.

    专利号:US-5484949-A
    优先权日:1993-01-29
    标题:Method for the synthesis of α β-unsaturated ketones
    发明人:TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI
    权利人:NIPPON SODA CO
    摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.

    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-11325912-B2
    优先权日:2019-05-09
    标题 :Regio-selective synthesis of imidazo[1,2-a]pyrimidines
    发明人:CLAGG KYLE BRADLEY PASCUAL; WHITE NICHOLAS ANDREW; ZHANG HAIMING; GOSSELIN FRANCIS; NACK WILLIAM; O'SHEA PAUL D
    权利人:GENENTECH INC
    摘要:A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb)comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

    专利号:WO-2025101716-A1
    优先权日:2023-11-07
    标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
    发明人:LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
    权利人:H LEE MOFFITT CANCER CT & RES
    摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

    专利号:US-12180182-B2
    优先权日:2021-12-01
    标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
    发明人:DAI MINGJI
    权利人:PURDUE RESEARCH FOUNDATION
    摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.
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    主要参考文献

    [参考文献]: Alan C Spivey, Et Al. A Strategy For Isotope Containment During Radiosynthesis--Devolatilisation Of Bromobenzene By Fluorous-Tagging-Ir-Catalysed Borylation En Route To The 4-Phenylpiperidine Pharmacophore. Org Biomol Chem. 2008 Nov 21;6(22):4093-5.
    [参考文献]: B L Blaylock, Et Al. Influence Of Cocaine History On The Behavioral Effects Of Dopamine D(3) Receptor-Selective Compounds In Monkeys. Neuropsychopharmacology. 2011 Apr;36(5):1104-13.
    [参考文献]: Fredrik Pettersson, Et Al. Synthesis And Evaluation Of A Set Of 4-Phenylpiperidines And 4-Phenylpiperazines As D2 Receptor Ligands And The Discovery Of The Dopaminergic Stabilizer 4-[参考文献]: G H Loew, Et Al. Structure-Activity Studies Of Morphine Fragments. I. 4-Alkyl-4-(M-Hydroxy-Phenyl)-Piperidines. Mol Pharmacol. 1988 Sep;34(3):363-76.
    [参考文献]: Karel Vervisch, Et Al. Radical-Mediated Nitrile Translocation As The Key Step In The Stereoselective Transformation Of 2-(4-Chloro-2-Cyanobutyl)Aziridines To Methyl Cis-(1-Arylmethyl-4-Phenylpiperidin-2-Yl)Acetates. Org Biomol Chem. 2012 Apr 28;10(16):3308-14.

    合成参考文献

    参考DOI号:10.1016/S0960-894X(00)00703-4
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