CAS: 6909-62-2; 2-(Dimethylamino)Ethyl Dihydrogen Phosphate

📜Dibenzyl 2-(Dimethylamino)Ethyl Phosphate置于氢气,Palladium(II) Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以87%的收率获得产物2-二甲基氨基乙基磷酸酯
参考文献:Structurally Diverse Low Molecular Weight Activators Of The Mammalian Pre-Mrna 3' Cleavage Reaction
标题:Structurally Diverse Low Molecular Weight Activators Of The Mammalian Pre-Mrna 3' Cleavage Reaction
摘要:The 3' End Formation Of Mammalian Pre-Mrna Contributes To Gene Expression Regulation By Setting The Downstream Boundary Of The 3' Untranslated Region,Which In Many Genes Carries Regulatory Sequences. A Large Number Of Protein Cleavage Factors Participate In This Pre-Mrna Processing Step,But Chemical Tools To Manipulate This Process Are Lacking. Guided By A Hypothesis That A Ppm1 Family Phosphatase Negatively Regulates The 3' Cleavage Reaction,We Have Found A Variety Of New Small Molecule Activators Of The In Vitro Reconstituted Pre-Mrna 3' Cleavage Reaction. New Activators Include A Cyclic Peptide Ppm1D Inhibitor,A Dipeptide With Modifications Common To Histone Tails,Abscisic Acid And An Improved L-Arginine Beta-Naphthylamide Analog. The Minimal Concentration Required For In Vitro Cleavage Has Been Improved From 200 Mu M To The 200 Nm-100 Mu M Range. These Compounds Provide Unexpected Leads In The Search For Small Molecule Tools Able To Affect Pre-Mrna 3' End Formation. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2013.12.006