CAS: 60145-22-4; 2,2',4,4',5,6'-Hexachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由合成有机化学品组成,以其环境持久性和潜在毒性著称,其特性为联苯结构中附带的六氯原子,多氯联苯154具有疏水性,使其在水中溶解性差,但在有机溶剂中可溶解;该化合物因其稳定性和降解耐受性而闻名,从而导致其在环境和生物生物体内的积累;多氯联苯154与各种有害健康影响有关,包括内分泌干扰和潜在的致癌性;在许多国家,由于环境和健康方面的考虑,其使用基本上受到禁止或限制;就物理特性而言,多氯联苯154一般是无色的,不光黄色固体或粘粘液,取决于其浓度和配制;该化合物在环境中的持久性引起了对食物链中生物蓄积性的关切,需要不断监测和研究其对生态系统和人类健康的影响.

英文名称2,2',4,4',5,6'-Hexachlorobiphenyl
中文名称2,2',4,4',5,6'-六氯联苯
IUPAC名称1,2,4-trichloro-5-(2,4,6-trichlorophenyl)benzene
其它别名2,2',4,4',5,6'-Hexachlorobiphenyl; 2,2',4,4',5',6-Hexachlorobiphenyl; 2,4,5,2',4',6'-Hexachlorobiphenyl
CAS编号60145-22-4
MFCD编号:MFCD00152540
EINECS号:690-234-5
FDA UNII编号:AGU550ZNJZ
分子式:C12H4Cl6分子量:360.88
产品CID: 1578150
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: QXZHEJWDLVUFFB-UHFFFAOYSA-N
InChI=1S/C12H4Cl6/c13-5-1-10(17)12(11(18)2-5)6-3-8(15)9(16)4-7(6)14/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS09;
注释: Health hazard & Environment
危险类别特定目标器官毒性-重复接触类别2
水生急性毒性类别1
水生慢性毒性类别1
警示词Warning(警告)
危险描述H373 |长期或反复接触可能损害器官.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
防范说明P273-P391-P501-P260-P314-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

欧盟法规

C&L通报

上下游产品

1,3,5-trichlorobenzene 2,4,5-trichloroaniline 1,3,7,8-tetrachlorodibenzofuran

合成工艺路线路线简述

合成目标产物 2,2',4,4',5,6'-Hexachlorobiphenyl 主要起始原料 1,3,5-Trichlorobenzene And 2,4,5-Trichloroaniline
(文献来源)合成步骤主要原料 1,3,5-Trichlorobenzene 和 2,4,5-Trichloroaniline

📜1,3,5-三氯苯,2,4,5-三氯苯胺置于亚硝酸异戊酯体系中,化学反应生成 2,2',4,4',5,6'-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4