CAS: 599-88-2; 4-Amino-N-(5-Methylpyrimidin-2-yl)Benzenesulfonamide

该化合物是属于硫化物类化合物的磺酰胺抗生素,其特点是它能够通过干扰对细菌细胞代谢至关重要的叶酸合成来抑制细菌生长,硫化物通常用于兽医学,并可用于治疗各种细菌感染,该化合物以其水中的中溶液和在标准条件下的稳定性而闻名,其化学结构具有对抗菌活动至关重要的磺酰胺组.与其他磺酰胺一样,硫化物可能产生副作用,包括过敏反应或胃肠扰动,而且其使用经常受到监测,以防止细菌抗药性的发展.

结构式图片

合成工艺路线路线简述

    📜对乙酰胺基苯磺酰氯置于sodium Hydroxide体系中,化学反应生成 磺胺培林
    参考文献:Sulfonamido Derivatives Of Pyrimidines
    标题:Sulfonamido Derivatives Of Pyrimidines
    摘要:
    DOI:10.1021/ja01856A046

    专利信息


    专利号:WO-0146695-A1
    优先权日:1999-12-08
    标 题:Novel supports for solid phase synthesis
    发明人:ANTONENKO VALERY V; THIELE JOCHEN; ATUEGBU ANDY E
    权利人:GLAXO GROUP LTD; ANTONENKO VALERY V; THIELE JOCHEN; ATUEGBU ANDY E
    摘要:Novel solid supports and methods for their use in the synthesis of chemical compounds by the sequential addition of chemical building blocks are provided. The solid support comprises a polymer having reactive groups (for example, poly(styrene-co-vinylbenzyl chloride)) grafted to a chemically inert bulk material (such as a Teflon® membrane).

    专利号:US-2007021349-A1
    优先权日:2005-04-28
    标题:Orthogonally protected bifunctional amino acid
    发明人:SRINIVASAN ANANTH; LUYT LEONARD G
    权利人:SRINIVASAN ANANTH; LUYT LEONARD G
    摘要:The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.

    专利号:US-9295731-B2
    优先权日:2013-04-01
    标题 :Cleavable drug conjugates, compositions thereof and methods of use
    发明人:NGUYEN MARK QUANG
    权利人:NGUYEN MARK QUANG
    摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

    专利号:WO-2006114323-A3
    优先权日:2005-04-28
    标题 :Orthogonally protected bifunctional amino acid
    发明人:SRINIVASAN ANANTH; LUYT LEONARD G
    权利人:SCHERING AG; SRINIVASAN ANANTH; LUYT LEONARD G
    摘要:The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding Compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.

    专利号:CN-1478772-A
    优先权日:2002-08-28
    标 题:Synthesis method of -N-phenyl-N'-pyridyl substituted carbamide derivative

    专利号:CN-1169796-C
    优先权日:2002-10-21
    标题:Catalytic synthesis process of methyl substituted pyrimidyl urea derivative

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Losch K. [Pharmacokinetic studies of sulfamerazine-Na, sulfaperine-Na and sulfadimidine-Na in the hen]. Arch Exp Veterinarmed. 1980;34(4):587-94. German. Danish.

    合成参考文献


    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    参考文献:10.1002/cptx.16
    摘要:Wages PA. Detecting Protein Sulfenylation in Cells Exposed to a Toxicant. Curr Protoc Toxicol. 2017 Feb 01;71():17.18.1–17.18.12.
    参考文献:10.1002/bies.10114
    摘要:Bermingham A, Derrick JP. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays. 2002 Jul;24(7):637–48. doi: 10.1002/bies.10114.
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