专利号:US-2007082943-A1 优先权日:2005-04-01 标 题:Process for preparation of substantially pure glimepiride 发明人:KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B 权利人:KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B 摘要:The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HCl and 4[-2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide (I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride usingS methanolic ammonia and glacial acetic acid to obtain highly pure Glimepiride Form I (I) having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.
专利号:US-9440991-B2 优先权日:2013-12-23 标 题:Synthesis of an antiviral compound 发明人:CAGULADA AMY; CHAN JOHANN; CHAN LINA; COLBY DENISE A; KARKI KAPIL KUMAR; KATO DARRYL; KEATON KATIE ANN; KONDAPALLY SUDHA; LEVINS CHRIS; LITTKE ADAM; MARTINEZ RUBEN; PCION DOMINIKA; REYNOLDS TROY; ROSS BRUCE; SANGI MICHAEL; SCHRIER ADAM J; SENG PAMELA; SIEGEL DUSTIN; SHAPIRO NATHAN; TANG DONALD; TAYLOR JAMES G; TRIPP JONATHAN; WALTMAN ANDREW W; YU LAWRENCE 权利人:GILEAD SCIENCES INC 摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
专利号:US-9388345-B2 优先权日:2012-07-03 标题:Hydrocarbon synthesis methods, apparatus, and systems 发明人:MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G 权利人:SARTEC CORP 摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.
专利号:US-9382491-B2 优先权日:2012-07-03 标题 :Hydrocarbon synthesis methods, apparatus, and systems 发明人:MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G 权利人:SARTEC CORP 摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a method for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.
专利号:US-2017210756-A1 优先权日:2013-12-23 标题 :Synthesis of an antiviral compound
专利号:EP-3087085-B1 优先权日:2013-12-23 标题 :Synthesis of a macrocyclic hcv ns3 inhibiting tripeptide
参考文献:10.1007/978-94-017-7276-1_10 摘要:Lim TK. Dioscorea bulbifera. 2016. In: Edible Medicinal and Non-Medicinal Plants. 参考文献:10.1007/978-94-017-6790-3_7 摘要:Broersma S. Calculation of and Errors in the Susceptibility. 1947. In: Magnetic Measurements on Organic Compounds. 参考文献:10.1007/978-981-97-0391-3_12 摘要:Sato H, Yoshida J, Yamagishi A. Use of Circularly Polarized Infrared Light to Liquid Crystals. 2024. In: Multi-dimensional Vibrational Circular Dichroism. 参考文献:10.1007/s41742-024-00613-6 摘要:Kumar R, De M. Enhanced Bioremediation of Commercial Diesel Contamination by Mixed Culture of Newly Isolated Providencia vermicola IITG20 and Pseudomonas aeruginosa IITG21 from Local Refinery Waste. Int J Environ Res. 2024 May 28;18(4). doi: 10.1007/s41742-024-00613-6.