CAS: 489469-34-3; (2S,5S)-5-Hydroxy-5-Deuterio-2-Aminovaleric Acid

上下游产品

(4S)-3-(benzyloxycarbonyl)-4-[(3S)-3-hydroxy-3-deuteriopropyl]-1,3-oxazolidin-5-one N-benzyloxycarbonyl-L-glutamic acid -5-oxooxazolidin-3-carbonsaeure-benzylester(S)-4-2'-(Chloroformyl)ethyl-5-oxooxazolidin-3-carbonsaeure-benzylester (S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acidL-prolineL-proline

📜(4S)-3-(Benzyloxycarbonyl)-4-[(3S)-3-Hydroxy-3-Deuteriopropyl]-1,3-Oxazolidin-5-One置于盐酸体系中,用 水 作为反应溶剂,化学反应 2.0H,以78%的收率获得产物dl-β-羟基正缬氨酸
参考文献:Biosynthesis Of 4-Methylproline In Cyanobacteria: Cloning Of Nose And Nosf Genes And Biochemical Characterization Of The Encoded Dehydrogenase And Reductase Activities
标题:Biosynthesis Of 4-Methylproline In Cyanobacteria: Cloning Of Nose And Nosf Genes And Biochemical Characterization Of The Encoded Dehydrogenase And Reductase Activities
摘要:The Biosynthesis Of The Unusual Amino Acid 4-Methylproline In The Nostoc Genus Of Cyanobacteria Was Investigated On The Genetic And Enzymatic Level. Two Genes Involved In The Biosynthesis Were Cloned And The Corresponding Enzymes,A Zinc-Dependent Long-Chain Dehydrogenase And A Delta(1)-Pyrroline-5-Carboxylic Acid (P5C) Reductase Homologue,Were Overexpressed In Escherichia Coli And Biochemically Characterized. Putative Substrates Were Synthesized To Test Enzyme Substrate Specificities,And Deuterium Labeling Studies Were Carried Out To Reveal The Stereospecificities Of The Enzymatic Reactions With Respect To The Substrates As Well As To The Coenzymes.
DOI:10.1021/jo026479Q