CAS: 4685-12-5; (S)-2-(2-Aminoacetamido)Succinic Acid

该化合物是一种由氨基酸甘油和L-阻隔酸组成的二酸,其特点是其在生物系统中的作用,特别是在细胞粘合和信号过程中的作用;该化合物的特点是来自单酸的碳信箱组和来自甘油的氨基组,这助长了其在生理pH的Zwitidicicial性质. 甘基-L-片酸经常因其与Integrins的相互作用而受到研究,这些蛋白质是细胞-伸缩矩阵粘合的蛋白,其结构允许它模仿某些蛋白的粘合点,使其在生物医学研究中,特别是在组织工程和再生医学中具有价值.此外,该化合物还可能显示出在生理条件下的溶性及稳定性等特性,而这些特性对于其在各种生物化学实验和治疗环境中的应用非常重要.总体而言,甘基 -- L-片硫酸是了解浸化相互作用及其在生物系统中的影响的重要模型化合物.

结构式图片

相似化合物

1366384-20-4 79731-35-4 60079-22-3

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CAS号131668-52-5 Z-Gly-Asp(OBu)-OH | CAS号67036-33-3 2-[(2-chloroace... | CAS号57618-13-0 Z-Gly-Asp(OBzl)-OBzl | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号56-84-8 L-天门冬氨酸 | CAS号56-40-6 甘氨酸 | CAS号99896-85-2 L-精氨酰甘氨酰-L-天冬氨酸

合成工艺路线路线简述

    Z-Gly-Asp(Obu)-Oh置于palladium On Activated Charcoal 氢气,对甲苯磺酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,反应生成 甘氨酰-L-天冬氨酸
    参考文献:Synthesis And Antiviral Activity Of Vp1 Fragments Of The Aphthous Fever Virus
    标题:Synthesis And Antiviral Activity Of Vp1 Fragments Of The Aphthous Fever Virus
    摘要:
    DOI:10.1007/bf02464250

    海关参考信息

    专利信息


    专利号:EP-2588602-A1
    优先权日:2010-07-01
    标题:Variants of glucoamylase
    发明人:DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN
    权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC
    摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

    专利号:US-2009069239-A1
    优先权日:2007-09-06
    标题 :Use of Iridoptin to Induce Toxicity in Insects
    发明人:BILIMORIA SHAN L
    权利人:UNIV TEXAS TECH
    摘要:Improved methods and compounds to control insects, involving a biological control method to induce toxicity in targeted insects using iridoptin. The present invention induces high levels of apoptosis and inhibition of host protein synthesis in insect cells. It is the first viral toxin against non-lepidopteran insects and is distinct from existing bacterial toxins, such as Bacillus thuringiensis toxins, which are not effective against most beetles, including the boll weevil, and the Baculoviridae, which is the main group of viruses currently used as biological control agents. Iridoptin will have use in the control of agricultural pests. It will increase productivity and reduce disease transfer by vectors and household pests. By extension it has application in cancer therapy and other medical treatments where apoptosis is critical to removal of certain cells.

    专利号:US-6087332-A
    优先权日:1997-12-23
    标 题 :Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
    发明人:GALLER LAWRENCE ISAAC
    摘要:Streptokinase derivatives having platelet glycoprotein binding domains adjacent to the termini of the streptokinase sequence. These derivatives produce higher local concentrations of plasmin in vivo as compared to unmodified streptokinase. Certain of the derivatives have high affinity for the GPIIB/IIIA receptor and low affinity for the fibronectin and vitronectin receptors. Others have substantially equivalent affinity for all three receptors. The derivatives are useful in treating thromboembolic disorders. The streptokinase derivatives can be made by recombinant techniques or by chemical synthesis or conjugation.

    专利号:CN-115073587-A
    优先权日:2022-07-08
    标 题 :A kind of synthetic process of semi-continuous liquid phase synthesis of bivalirudin

    专利号:US-9751911-B2
    优先权日:2012-11-27
    标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof
    发明人:REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN
    权利人:COUNCIL SCIENT IND RES
    摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

    专利号:CA-2394414-A1
    优先权日:1999-12-16
    标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids
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    合成参考文献


    参考文献:10.1023/b:rubi.0000023094.72361.c7
    摘要:Stepanenko EG, Sebiakin IuL. [Synthesis of lipophilic RGD-peptide derivatives]. Bioorg Khim. 2004 Mar;30(2):126–9. doi: 10.1023/b:rubi.0000023094.72361.c7.
    参考文献:10.1021/jm0511029
    摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029.
    参考文献:10.1186/s40793-017-0220-z|10.1186/s40793-017-0283-x
    摘要:Aserse AA, Woyke T, Kyrpides NC, Whitman WB, Lindström K. Draft genome sequences of Bradyrhizobium shewense sp. nov. ERR11T and Bradyrhizobium yuanmingense CCBAU 10071T. Environmental Microbiome. 2017 Dec 05;12(1):74. doi: 10.1186/s40793-017-0283-x.
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