CAS: 38345-66-3; (2S,3R)-4-(Dimethylamino)-3-Methyl-1,2-Diphenylbutan-2-Ol

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CAS号126-04-5 alpha-[2-(dimet... | CAS号124-40-3 二甲胺 | CAS号98-59-9 对甲苯磺酰氯(PTSC)

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于palladium On Activated Charcoal,溶剂黄146体系中,化学反应生成(2S,3R)-(+)-4-二甲氨基-1,2-二苯基-3-甲基-2-丁醇
参考文献:Analgesics: α-Dl-4-Dimethylamino-1,2-Diphenyl-3-Methyl-2-Propionoxybutane-N-Methyl-C14
标题:Analgesics: α-Dl-4-Dimethylamino-1,2-Diphenyl-3-Methyl-2-Propionoxybutane-N-Methyl-C14
摘要:
Doi:10.1021/ja01563A045

专利信息

专利号:US-4727146-A
优先权日:1980-07-03
标题 :Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
发明人：RICE KENNER C
权利人:US HEALTH
摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids. As a special function of this invention, certain of the derivatives, namely 4'-6' and 7'-9', may be hydrogenated to 1'-3' derivative by asymmetric reduction either of the catalytic or chemical type.

专利号:US-2011165641-A1
优先权日:2006-03-31
标 题 :Synthesis of 1,2,4-Butanetriol Enantiomers from Carbohydrates
发明人：FROST JOHN W
权利人:UNIV MICHIGAN STATE
摘要:A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.

专利号:US-6444820-B1
优先权日:1995-04-07
标题:Process for the manufacture of camptothecin derivatives
发明人：HENEGAR KEVIN E; SIH JOHN C
摘要:This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as a novel method of making mappicine.

专利号:US-5132457-A
优先权日:1991-08-26
标 题 :Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP)
发明人：MATHEW JACOB
权利人:MALLINCKRODT SPEC CHEM
摘要:In a method for producing 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP), a chiral ester of the formula ##STR1## wherein R is an alkyl of from 1 to about 5 carbon atoms, is provided. The chiral easter of formula (I) is converted into a chiral amino-alcohol of the formula ##STR2## and the chiral amino-alcohol is oxidized so as to form d-DAMP.

专利号:US-5162566-A
优先权日:1991-08-26
标 题 :Stereospecific synthesis of tetrasubstituted acrylic esters
发明人：MATHEW JACOB
权利人:MALLINCKRODT SPEC CHEM
摘要:Substantially stereospacific (E)-tetrasubstituted acrylic esters, such as (II) where R is hydrogen alkyl, R1 is alkyl, aryl or aralkyl, R2 and R4 are alkyl, are formed from racemic mixtures of corresponding unsaturated esters and cuprates of the formula (R3)2CuX, wherein R3 is alkyl, aryl or aralkyl, and X is lithium or magnesium halide.

专利号:US-2006234363-A1
优先权日:2003-10-01
标题:Synthesis of 1,2,4-butanetriol enantiomers from carbohydrates