CAS: 37067-30-4; 4-Methylumbelliferyl 2-Acetamido-2-Deoxy-ß-D-Glucopyranoside

上下游产品

4-methylumbelliferyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranoside 4-methylumbelliferyl β-D-N,N′,N′′-triacetylchitotrioside 7-hydroxy-4-methyl-chromen-2-one Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-chloro-tetrahydro-pyran-4-yl ester 4)-2-acetamido-2-deoxy-β-D-glucopyranoside4-methylumbelliferyl β-D-galactopyranosyl-(1-4)-2-acetamido-2-deoxy-β-D-glucopyranoside 7-hydroxy-4-methyl-chromen-2-one 4-methylumbellifer-7-yl-β-D-cellobioside 4-methylumbelliferyl 2-acetamido-2-deoxy-3-O-(methyl 2,3-di-O-benzoyl-4-deoxy-β-D-glucopyranosyl uronate)-4,6-O-di-tert-butylsilanediyl-β-D-glucopyranoside

📜4-Methylumbelliferyl 2-Amino-2-Deoxy-β-D-Glucopyranoside Hydrochloride置于sodium Methylate,三乙胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 4-甲基香豆素-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷
参考文献:Pugnac 和 Nag-噻唑啉作为 Humano-Glcnacase 过渡态类似物的分析:对抑制剂选择性和过渡态平衡的机制和结构见解
标题:Pugnac 和 Nag-噻唑啉作为 Humano-Glcnacase 过渡态类似物的分析:对抑制剂选择性和过渡态平衡的机制和结构见解
摘要:O-Glcnacase 催化 β-O-连接的 2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷 (O-Glcnac) 从翻译后修饰蛋白的丝氨酸和苏氨酸残基中裂解.这种酶的两种有效抑制剂是 O-(2-Acetamido-2-Deoxy-D-Glupyranosylidene)Amino-N-Phenylcarbamate (Pugnac) 和 1,2-Dideoxy-2'-Methyl-Alpha-D-Glupyranoso[2,1-D]-Delta2'-噻唑啉(nag-噻唑啉).这些抑制剂的衍生物对人 O-Glcnacase 的选择性与功能相关的人溶酶体 β-己糖胺酶的选择性不同,Pugnac 衍生物表现出适度的选择性,而 Nag-噻唑啉衍生物表现出高选择性.解决了这种选择性差异的分子基础,以及这些抑制剂模拟 O-Glcnacase 稳定的过渡态 (Ts) 的程度.使用一系列基板,基态 (Gs)
DOI:10.1021/ja065697O

专利信息

专利号:US-2023122862-A1
优先权日:2021-10-12
标 题:Treatment of ige-mediated diseases
发明人：KUO BE-SHENG; LI CHAO-HUNG; LI YWAN-FENG; LYNN SHUGENE; WANG CHANG YI
权利人:UNITED BIOPHARMA INC
摘要:The present invention relates to the treatment of IgE mediated diseases using an anti-IgE antibody. In particular, the anti-IgE antibody is a multifunctional antibody against IgE, which neutralizes IgE and inhibits IgE synthesis. Specifically, the treatment of the present invention is effective in providing a rapid and/or sustained suppression of disease symptoms.

专利号:EP-1190248-B1
优先权日:1999-06-29
标 题 :Screening methods for compounds which affect melanogenesis
发明人：ORLOW SETH J; MANGA PRASHIELA
权利人:UNIV NEW YORK
摘要:Methods of screening for compounds that affect melanogenesis and the function of P protein in organisms, cells, or cell-free systems are provided. The invention further relates to the pharmacologic and cosmetic uses of such compounds to reduce or increase the synthesis of melanin in animal and human melanocytes and melanocyte-derived cells.